2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide

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Chemical Name:2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide
CAS No.:1562399-27-2
Molecular Formula:C₂₆H₂₇F₇N₄O₃
Molecular Weight:576.514
Hs Code.:

Synonyms:2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide

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Chemical Property of 2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide

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Technology Process of 2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide

There total 7 articles about 2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 6-(5-fluoro-2-methylphenyl)-6-methyl-4-trifluoromethylhept-1-yn-4-ol

: 2,2,2-trifluoro-N-(4-chloro-2-morpholin-4-yl-pyrimidin-5-yl)acetamide

: 1562399-27-2
2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jm4019178

Reference yield:

: 400-31-7
1,1,1-trifluoro-4-methyl-pent-3-en-2-one

: 1562399-27-2
2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide / diethyl ether; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

2: diethyl ether / 15 h / -78 - 20 °C / Inert atmosphere

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/jm4019178

Reference yield:

: 186496-59-3
(5-fluoro-2-methylphenyl)magnesium bromide

: 1562399-27-2
2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide / diethyl ether; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

2: diethyl ether / 15 h / -78 - 20 °C / Inert atmosphere

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/jm4019178