(R)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(2-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol

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Chemical Name:(R)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(2-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol
CAS No.:1562399-28-3
Molecular Formula:C₂₄H₂₈F₄N₄O₂
Molecular Weight:480.506
Hs Code.:

Synonyms:(R)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(2-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol

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Chemical Property of (R)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(2-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol

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Technology Process of (R)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(2-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol

There total 8 articles about (R)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(2-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1562399-27-2
2,2,2-trifluoro-N-{4-[(S)-6-(5-fluoro-2-methylphenyl)-4-hydroxy-6-methyl-4-trifluoromethylhept-1-ynyl]-2-morpholin-4-yl-pyrimidin-5-yl}acetamide

: 1562399-28-3
(R)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(2-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol

Guidance literature:: With N,N,N',N'-tetramethylguanidine; In 1,4-dioxane; at 100 ℃; for 0.75h; Inert atmosphere;
DOI:10.1021/jm4019178

Reference yield:

: 4-(4-chloro-5-nitro-2-pyrimidinyl)morpholine

: 1562399-28-3
(R)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(2-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; tin(II) chloride dihdyrate; acetic acid / water / 18 h / 20 °C / Inert atmosphere

2: dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

4: N,N,N',N'-tetramethylguanidine / 1,4-dioxane / 0.75 h / 100 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tin(II) chloride dihdyrate; acetic acid; triethylamine; N,N,N',N'-tetramethylguanidine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/jm4019178

Reference yield:

: 186496-59-3
(5-fluoro-2-methylphenyl)magnesium bromide

: 1562399-28-3
(R)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-(2-morpholin-4-yl-5H-pyrrolo[3,2-d]pyrimidin-6-ylmethyl)pentan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide / diethyl ether; tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

2: diethyl ether / 15 h / -78 - 20 °C / Inert atmosphere

3: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

4: N,N,N',N'-tetramethylguanidine / 1,4-dioxane / 0.75 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/jm4019178