methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate

Base Information

Chemical Name:methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate
CAS No.:1541198-04-2
Molecular Formula:C₁₆H₁₉ClO₅
Molecular Weight:326.777
Hs Code.:

Synonyms:methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate

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Chemical Property of methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate

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Technology Process of methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate

There total 3 articles about methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 110238-91-0
tetrahydropyran-4-carboxylic acid methyl ester

: 230642-94-1
2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile

: 1541198-04-2
methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: tetrahydropyran-4-carboxylic acid methyl ester; With n-butyllithium; N-cyclohexyl-cyclohexanamine; In hexane; toluene; at 0 - 25 ℃; for 0.0833333h; Inert atmosphere;

2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In hexane; toluene; for 1h; Inert atmosphere;

Reference yield:

: 188813-05-0
3-bromo-5-chloro-benzaldehyde

: 1541198-04-2
methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux; Dean-Stark

2.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

With n-butyllithium; toluene-4-sulfonic acid; N-cyclohexyl-cyclohexanamine; In hexane; toluene;

Reference yield:

: 14862-52-3
1,3-dibromo-5-chlorobenzene

: 1541198-04-2
methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux; Dean-Stark

3.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere

With n-butyllithium; toluene-4-sulfonic acid; N-cyclohexyl-cyclohexanamine; In hexane; di-isopropyl ether; toluene;