2-(3-Bromo-5-chlorophenyl)-1,3-dioxolane

Base Information

Chemical Name:2-(3-Bromo-5-chlorophenyl)-1,3-dioxolane
CAS No.:230642-94-1
Molecular Formula:C₉H₈BrClO₂
Molecular Weight:263.518
Hs Code.:
DSSTox Substance ID:DTXSID401274763

Synonyms:2-(3-bromo-5-chlorophenyl)-1,3-dioxolane;230642-94-1;SCHEMBL6208359;ITWDCENUEYGQAZ-UHFFFAOYSA-N;DTXSID401274763;MFCD28360678;CS-0450160;2-(3-bromo-5-chloro-phenyl)-[1,3]dioxolane;E93476

Suppliers and Price of 2-(3-Bromo-5-chlorophenyl)-1,3-dioxolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-(3-Bromo-5-chlorophenyl)-1,3-dioxolane

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:261.93962
Heavy Atom Count:13
Complexity:173

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COC(O1)C2=CC(=CC(=C2)Br)Cl

Technology Process of 2-(3-Bromo-5-chlorophenyl)-1,3-dioxolane

There total 2 articles about 2-(3-Bromo-5-chlorophenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 188813-05-0
3-bromo-5-chloro-benzaldehyde

: 230642-94-1
2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile

Guidance literature:: With toluene-4-sulfonic acid; In 1,2-dimethoxyethane; toluene; at 25 - 140 ℃; for 3h; Inert atmosphere;

Reference yield:

: 14862-52-3
1,3-dibromo-5-chlorobenzene

: 230642-94-1
2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux; Dean-Stark

With n-butyllithium; toluene-4-sulfonic acid; In hexane; di-isopropyl ether; toluene;

Reference yield: 70.0%

: 110238-91-0
tetrahydropyran-4-carboxylic acid methyl ester

: 230642-94-1
2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile

: 1541198-04-2
methyl 4-(3-chloro-5-(1,3-dioxolan-2-yl)phenyl)tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: tetrahydropyran-4-carboxylic acid methyl ester; With n-butyllithium; N-cyclohexyl-cyclohexanamine; In hexane; toluene; at 0 - 25 ℃; for 0.0833333h; Inert atmosphere;

2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; In hexane; toluene; for 1h; Inert atmosphere;