4-tert-butyl-N-(3-{5-[4-(4-hydroxy-piperidine-1-carbonyl)-phenylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-methyl-phenyl)-benzamide

Base Information

Chemical Name:4-tert-butyl-N-(3-{5-[4-(4-hydroxy-piperidine-1-carbonyl)-phenylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-methyl-phenyl)-benzamide
CAS No.:910232-68-7
Molecular Formula:C₃₆H₄₀N₄O₄
Molecular Weight:592.738
Hs Code.:

Synonyms:4-tert-butyl-N-(3-{5-[4-(4-hydroxy-piperidine-1-carbonyl)-phenylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-methyl-phenyl)-benzamide

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Chemical Property of 4-tert-butyl-N-(3-{5-[4-(4-hydroxy-piperidine-1-carbonyl)-phenylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-methyl-phenyl)-benzamide

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Technology Process of 4-tert-butyl-N-(3-{5-[4-(4-hydroxy-piperidine-1-carbonyl)-phenylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-methyl-phenyl)-benzamide

There total 8 articles about 4-tert-butyl-N-(3-{5-[4-(4-hydroxy-piperidine-1-carbonyl)-phenylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-methyl-phenyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 910232-70-1
4-[(5-{3-[(4-tert-butylbenzene)amido]-2-methylphenyl}-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)amino]benzoic acid

: 910232-68-7
4-tert-butyl-N-(3-{5-[4-(4-hydroxy-piperidine-1-carbonyl)-phenylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-methyl-phenyl)-benzamide

Guidance literature:: 4-[(5-{3-[(4-tert-butylbenzene)amido]-2-methylphenyl}-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)amino]benzoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-HYDROXYPIPERIDINE; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 14529-54-5
3,5-dibromo-1-methyl-1H-pyridin-2-one

: 910232-68-7
4-tert-butyl-N-(3-{5-[4-(4-hydroxy-piperidine-1-carbonyl)-phenylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-methyl-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 0.25 h

1.2: 48 h / 120 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 100 °C

3.1: sodium hydroxide; water / ethanol / 1.5 h / Heating / reflux

3.2: pH 5

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 16 h / 20 °C

With sodium hydroxide; water; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 13472-81-6
3,5-dibromo-2-hydroxypyridine

: 910232-68-7
4-tert-butyl-N-(3-{5-[4-(4-hydroxy-piperidine-1-carbonyl)-phenylamino]-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl}-2-methyl-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 18 h / 20 °C

2.1: toluene / 0.25 h

2.2: 48 h / 120 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 100 °C

4.1: sodium hydroxide; water / ethanol / 1.5 h / Heating / reflux

4.2: pH 5

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 16 h / 20 °C

With sodium hydroxide; water; sodium carbonate; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;