3,5-Dibromo-2-hydroxypyridine

Base Information

• Chemical Name: 3,5-Dibromo-2-hydroxypyridine
• CAS No.: 13472-81-6
• Molecular Formula: C5H3Br2NO
• Molecular Weight: 252.893
• Hs Code.: 29333999
• European Community (EC) Number: 634-378-9
• DSSTox Substance ID: DTXSID50349077
• Nikkaji Number: J81.623J
• Wikidata: Q72464982
• Mol file: 13472-81-6.mol

Synonyms:3,5-Dibromo-2-hydroxypyridine;13472-81-6;3,5-dibromopyridin-2-ol;3,5-Dibromo-2-pyridinol;3,5-dibromo-2(1H)-pyridinone;2-Hydroxy-3,5-dibromopyridine;3,5-dibromo-1H-pyridin-2-one;3,5-Dibromo-2-pyridone;MFCD00023472;2(1H)-Pyridinone, 3,5-dibromo-;3,5,-Dibromo-2-pyridinol;2-pyridinol, 3,5-dibromo-;3,5,-Dibromo -2-pyridinol;SCHEMBL1038352;SCHEMBL8150851;3,5-Dibromo-2(1H)-pyridone;3,5-dibromopyridin-2(1H)-one;DTXSID50349077;3,5-dibromo pyridin-2(1H)-one;AKOS000267470;3,5-bis(bromanyl)-1H-pyridin-2-one;AB01360;AC-6264;CS-W002137;AM803167;AS-19531;SY028336;D2918;FT-0636898;EN300-134402;A806833;AE-641/02443049;W-205452

Chemical Property of 3,5-Dibromo-2-hydroxypyridine

Chemical Property:

• Appearance/Colour: beige to light brown crystalline powder
• Vapor Pressure: 0.00208mmHg at 25°C
• Melting Point: 204-210 °C
• Refractive Index: 1.672
• Boiling Point: 305.359 °C at 760 mmHg
• PKA: 8.48±0.10(Predicted)
• Flash Point: 138.477 °C
• PSA: 33.12000
• Density: 2.229 g/cm³
• LogP: 2.31220
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 252.85609
• Heavy Atom Count: 9
• Complexity: 207

Purity/Quality:

97% ^*data from raw suppliers

3,5-Dibromo-2-hydroxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22-20/21/22
• Safety Statements: 37/39-26-36-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=C(C(=O)NC=C1Br)Br

Technology Process of 3,5-Dibromo-2-hydroxypyridine

There total 18 articles about 3,5-Dibromo-2-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-hydroxypyridin (142-08-5) → 3,5-dibromo-2-hydroxypyridine (13472-81-6)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; at 20 ℃; for 48h;

DOI:10.1055/s-2001-18070

Reference yield: 85.0%

2-Pyridone (142-08-5,1199357-22-6) → 3,5-dibromo-2-hydroxypyridine (13472-81-6)

Guidance literature:

With bromine; In acetic acid;

DOI:10.1021/ja00379a016

Reference yield: 81.0%

2-hydroxypyridin (142-08-5) → 3,5-dibromo-2-hydroxypyridine (13472-81-6)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 5 - 20 ℃; Large scale;

upstream raw materials:

2-Pyridone

2-amino-3,5-dibromopyridine

(6-hydroxy-[3]pyridyl)-arsonic acid

2-hydroxypyridin

Downstream raw materials:

3,5-dibromo-1-methyl-1H-pyridin-2-one

2-chloro-3,5-dibromopyridine

3-bromo-pyridin-2-ol

toluene-4-sulfonic acid 3-benzoyl-5-bromo-pyridin-2-yl ester