1-((2R,3R)-3-Benzyloxymethoxy-2-methyl-butane-1-sulfonyl)-4-methyl-benzene

Base Information

Chemical Name:1-((2R,3R)-3-Benzyloxymethoxy-2-methyl-butane-1-sulfonyl)-4-methyl-benzene
CAS No.:114972-50-8
Molecular Formula:C₂₀H₂₆O₄S
Molecular Weight:362.49
Hs Code.:

Synonyms:1-((2R,3R)-3-Benzyloxymethoxy-2-methyl-butane-1-sulfonyl)-4-methyl-benzene

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Chemical Property of 1-((2R,3R)-3-Benzyloxymethoxy-2-methyl-butane-1-sulfonyl)-4-methyl-benzene

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Technology Process of 1-((2R,3R)-3-Benzyloxymethoxy-2-methyl-butane-1-sulfonyl)-4-methyl-benzene

There total 8 articles about 1-((2R,3R)-3-Benzyloxymethoxy-2-methyl-butane-1-sulfonyl)-4-methyl-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 114972-49-5
((1R,2R)-3-Bromo-1,2-dimethyl-propoxymethoxymethyl)-benzene

: 824-79-3
sodium 4-methylbenzenesulfinate

: 114972-50-8
1-((2R,3R)-3-Benzyloxymethoxy-2-methyl-butane-1-sulfonyl)-4-methyl-benzene

Guidance literature:: With tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 40 ℃; for 8h;
DOI:10.1016/S0040-4020(01)90315-1

Reference yield:

: 114972-44-0
(2S,3S)-1-(benzyloxy)-4-[(tert-butyldimethylsilyl)oxy]-3-methylbutan-2-ol

: 114972-50-8
1-((2R,3R)-3-Benzyloxymethoxy-2-methyl-butane-1-sulfonyl)-4-methyl-benzene

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂ / Pd(OH)2/C / ethanol / 4 h

2: 92 percent / pyridine / -20 °C

3: 84 percent / LiB(Et)3H / tetrahydrofuran / 0.5 h / 0 °C

4: 72 percent / diisopropylethyl amine / CH₂Cl₂ / Ambient temperature

5: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1) 0 deg C, 1 h, 2) room temperature, 2 h

6: 92 percent / CBr₄/PPh₃ / CH₂Cl₂ / 1 h / -40 °C

7: 80 percent / tetrabutylammonium bromide / dimethylformamide / 8 h / 40 °C

With pyridine; carbon tetrabromide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; hydrogen; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)90315-1

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 114972-50-8
1-((2R,3R)-3-Benzyloxymethoxy-2-methyl-butane-1-sulfonyl)-4-methyl-benzene

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / diisopropylethyl amine / CH₂Cl₂ / Ambient temperature

2: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1) 0 deg C, 1 h, 2) room temperature, 2 h

3: 92 percent / CBr₄/PPh₃ / CH₂Cl₂ / 1 h / -40 °C

4: 80 percent / tetrabutylammonium bromide / dimethylformamide / 8 h / 40 °C

With carbon tetrabromide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)90315-1