5-[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]isothiazol-3-ol 1-oxide

Base Information

Chemical Name:5-[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]isothiazol-3-ol 1-oxide
CAS No.:1312787-86-2
Molecular Formula:C₁₆H₉ClF₃NO₃S
Molecular Weight:387.767
Hs Code.:

Synonyms:5-[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]isothiazol-3-ol 1-oxide

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Chemical Property of 5-[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]isothiazol-3-ol 1-oxide

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Technology Process of 5-[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]isothiazol-3-ol 1-oxide

There total 2 articles about 5-[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]isothiazol-3-ol 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-chloroisothiazol-3-ol 1-oxide

: 1312789-53-9
[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]boronic acid

: 1312787-86-2
5-[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]isothiazol-3-ol 1-oxide

Guidance literature:: 5-chloroisothiazol-3-ol 1-oxide; [4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]boronic acid; With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; at 90 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; water; pH=2;

Reference yield:

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 78068-85-6
3-chloro-4-fluoro benzotrifluoride

: 1312787-86-2
5-[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]isothiazol-3-ol 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 20 h / 130 °C

1.2: pH 2

2.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 1 h / 90 °C

2.2: pH 2

With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; dimethyl sulfoxide;