(S)-6-Benzyl-6-aza-spiro[2.5]octan-4-ol

Base Information

Chemical Name:(S)-6-Benzyl-6-aza-spiro[2.5]octan-4-ol
CAS No.:1101840-81-6
Molecular Formula:C₁₄H₁₉NO
Molecular Weight:217.311
Hs Code.:

Synonyms:(S)-6-Benzyl-6-aza-spiro[2.5]octan-4-ol

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Chemical Property of (S)-6-Benzyl-6-aza-spiro[2.5]octan-4-ol

Chemical Property:

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Technology Process of (S)-6-Benzyl-6-aza-spiro[2.5]octan-4-ol

There total 6 articles about (S)-6-Benzyl-6-aza-spiro[2.5]octan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1101840-77-0
6-benzyl-6-aza-spiro[2.5]octan-4-one hydrochloride

: 1101840-81-6
(S)-6-Benzyl-6-aza-spiro[2.5]octan-4-ol

Guidance literature:: 6-benzyl-6-aza-spiro[2.5]octan-4-one hydrochloride; With sodium hydroxide; NADH; ketoreductase KRED-NADH-117; In water; isopropyl alcohol; at 35 ℃; for 24h; pH=8; TRIS-HCl buffer;

With NADH; magnesium chloride; ketoreductase KRED-NADH-117; In water; isopropyl alcohol; for 96h; TRIS-HCl buffer;

Reference yield:

: 108546-98-1
1-allyl-cyclopropanecarboxylic acid tert-butyl ester

: 1101840-81-6
(S)-6-Benzyl-6-aza-spiro[2.5]octan-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: ozone / dichloromethane; methanol / -72 °C

1.2: 20 °C / Inert atmosphere

2.1: sodium tris(acetoxy)borohydride / ethyl acetate; toluene / 5 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.5 h / 20 - 25 °C

3.2: -10 - 40 °C

3.3: 0 - 20 °C

4.1: sodium hydroxide / ketoreductase KRED-NADH-117 / isopropyl alcohol / 24 h / 35 °C / pH 8 / Aqueous buffer

4.2: 96 h

With sodium tris(acetoxy)borohydride; ozone; sodium hydroxide; lithium hexamethyldisilazane; ketoreductase KRED-NADH-117; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

: 7662-76-2
tert-butyl 2-(benzylamino)acetate

: 1101840-81-6
(S)-6-Benzyl-6-aza-spiro[2.5]octan-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride / ethyl acetate; toluene / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.5 h / 20 - 25 °C

2.2: -10 - 40 °C

2.3: 0 - 20 °C

3.1: sodium hydroxide / ketoreductase KRED-NADH-117 / isopropyl alcohol / 24 h / 35 °C / pH 8 / Aqueous buffer

3.2: 96 h

With sodium tris(acetoxy)borohydride; sodium hydroxide; lithium hexamethyldisilazane; ketoreductase KRED-NADH-117; In tetrahydrofuran; ethyl acetate; isopropyl alcohol; toluene;