4-[(5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-yl)oxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide diethylamine salt

Base Information

Chemical Name:4-[(5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-yl)oxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide diethylamine salt
CAS No.:1446444-39-8
Molecular Formula:C₄H₁₁N*C₁₈H₁₉ClF₃N₃O₅S
Molecular Weight:555.018
Hs Code.:

Synonyms:4-[(5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-yl)oxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide diethylamine salt

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Chemical Property of 4-[(5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-yl)oxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide diethylamine salt

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Technology Process of 4-[(5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-yl)oxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide diethylamine salt

There total 2 articles about 4-[(5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-yl)oxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide diethylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355067-74-1
5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-ol

: 1443430-94-1
N-[(dimethylamino)sulfonyl]-2,4,5-triifluorobenzamide

: 109-89-7
diethylamine

: 1446444-39-8
4-[(5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-yl)oxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide diethylamine salt

Guidance literature:: 5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-ol; N-[(dimethylamino)sulfonyl]-2,4,5-triifluorobenzamide; With potassium carbonate; In dimethyl sulfoxide; at 90 ℃; for 18h; Inert atmosphere;

diethylamine; In water; acetonitrile;

Reference yield:

: 1355068-21-1
3-chloro-2-(2-fluoro-2-methylpropoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1446444-39-8
4-[(5-chloro-6-(2-fluoro-2-methylpropoxy)pyridin-3-yl)oxy]-N-[(dimethylamino)sulfonyl]-2,5-difluorobenzamide diethylamine salt

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide / methanol; water / 3 h / 0 - 20 °C

2: potassium carbonate / dimethyl sulfoxide / 18 h / 90 °C / Inert atmosphere

With dihydrogen peroxide; potassium carbonate; In methanol; water; dimethyl sulfoxide;