2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

Base Information

Chemical Name:2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid
CAS No.:287119-99-7
Molecular Formula:C₁₈H₁₈N₂O₇
Molecular Weight:374.35
Hs Code.:

Synonyms:2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

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Chemical Property of 2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

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Technology Process of 2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

There total 5 articles about 2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 287119-95-3
methyl 2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate

: 287119-99-7
2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

Guidance literature:: With sodium hydroxide; water; In methanol; at 20 ℃;
DOI:10.1039/b000135j

Reference yield:

: 138563-98-1
methyl 2-methoxy-5-nitrophenylacetate

: 287119-99-7
2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C / ethanol / 3102.97 Torr

2: tetrahydrofuran / -20 °C

3: BH₃*DMS / tetrahydrofuran / 20 °C

4: 95 percent / tetrahydrofuran / 20 °C

5: 97 percent / NaOH; H₂O / methanol / 20 °C

With sodium hydroxide; dimethylsulfide borane complex; water; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 1: Reduction / 2: Formylation / 3: Reduction / 4: Acylation / 5: Hydrolysis;
DOI:10.1039/b000135j

Reference yield:

: 138563-97-0
(5-amino-2-methoxy-phenyl)-acetic acid methyl ester

: 287119-99-7
2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / -20 °C

2: BH₃*DMS / tetrahydrofuran / 20 °C

3: 95 percent / tetrahydrofuran / 20 °C

4: 97 percent / NaOH; H₂O / methanol / 20 °C

With sodium hydroxide; dimethylsulfide borane complex; water; In tetrahydrofuran; methanol; 1: Formylation / 2: Reduction / 3: Acylation / 4: Hydrolysis;
DOI:10.1039/b000135j