138563-98-1

Upstream product

• 51794-07-1 2-hydroxy-5-nitrophenylacetic acid 
• 77-78-1 dimethyl sulfate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 614-75-5 2-Hydroxyphenylacetic acid 

Downstream Products

• 287120-11-0 N-[2-(N,N-dimethylamino)ethyl]-2-methoxy-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetamide 
• 287119-99-7 2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetic acid 
• 287119-95-3 methyl 2-methoxy-5-[N-methyl-N-(4-nitrobenzyloxycarbonyl)]aminophenylacetate 
• 755030-07-0 methyl 2-(2-methoxy-5-nitrophenyl)-2-methylpropanoate 
• 755029-88-0 methyl [5-(acetylamino)-2-methoxyphenyl]acetate 
• 287120-07-4 2-methoxy-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetic acid 
• 287120-03-0 methyl 2-methoxy-5-[N-methyl-N-(tert-butyloxycarbonyl)]aminophenylacetate 
• 287119-91-9 methyl 2-methoxy-5-(N-methylamino)phenylacetate 
• 138563-97-0 (5-amino-2-methoxy-phenyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors

The synthesis and structure-activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this previously disclosed core afforded compounds with improved enzymatic and cellular potency.

HETEROCYCLIC KINASE INHIBITORS

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Leaving group effects in reductively triggered fragmentation of 4-nitrobenzyl carbamatesf

The rates and extent of release of a series of substituted anilines from 4-nitrobenzyl carbamates, following nitro group reduction by radiolytic, enzymic and chemical methods, are reported. The yield of released anilines decreased over the pH range 4-7, b

N-phenyl-N-acetamidoglycinamides, their preparation and medicaments containing them

Compounds of formula: STR1 in which R1 represents a hydrogen atom or an alkyl, alkoxycarbonyl or an unsubstituted or substituted phenyl radical, R2 represents a hydrogen atom or an unsubstituted or substituted alkyl radical, R3 represents an alkyl, phenylalkyl, indanyl, cycloalkylalkyl or an unsubstituted or substituted phenyl radical, or R2 and R3 form a heterocycle together with the nitrogen atom to which they are attached, and R4 represents an unsubstituted or substituted phenyl radical, a naphthyl, indolyl or quinolyl radical or a phenylamino radical in which the phenyl ring is unsubstituted or substituted, their preparation and medicaments containing them.