1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-((methylsulfonyl)imino)-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane

Base Information

Chemical Name:1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-((methylsulfonyl)imino)-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane
CAS No.:152455-78-2
Molecular Formula:C₂₉H₂₃BrN₂O₇S
Molecular Weight:623.481
Hs Code.:

Synonyms:1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-((methylsulfonyl)imino)-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane

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Chemical Property of 1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-((methylsulfonyl)imino)-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane

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Technology Process of 1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-((methylsulfonyl)imino)-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane

There total 7 articles about 1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-((methylsulfonyl)imino)-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3144-09-0
methanesulfonamide

: 152455-76-0
8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone

: 152455-78-2
1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-((methylsulfonyl)imino)-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane

Guidance literature:: With titanium tetrachloride; triethylamine; In dichloromethane; at 0 - 25 ℃; for 6.5h;
DOI:10.1021/ja00076a035

Reference yield: 59.0%

: 676-85-7
methylsulphinyl chloride

: 1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-hydroxyimino-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane

: 152455-78-2
1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-((methylsulfonyl)imino)-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane

Guidance literature:: With triethylamine; In dichloromethane; at 2 - 24 ℃; for 1.25h;
DOI:10.1021/ja00076a035

Reference yield:

: 19283-70-6
3,4-dimethoxysalicylaldehyde

: 152455-78-2
1-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-1-((methylsulfonyl)imino)-1-(7',8'-dimethoxy-2'-oxo-2'H-1'-benzopyran-3'-yl)methane

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / piperidine / ethanol / 1 h / Heating

2: 75 percent / TiCl₄, Et₃N / CH₂Cl₂ / 6.5 h / 0 - 25 °C

With piperidine; titanium tetrachloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1021/ja00076a035