8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone

Base Information

Chemical Name:8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone
CAS No.:152455-76-0
Molecular Formula:C₂₈H₂₀BrNO₆
Molecular Weight:546.374
Hs Code.:

Synonyms:8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone

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Chemical Property of 8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone

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Technology Process of 8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone

There total 4 articles about 8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 19283-70-6
3,4-dimethoxysalicylaldehyde

: 152455-75-9
ethyl 3-(8'-(benzyloxy)-7'-bromoquinolin-2'-yl)-3-oxopropionate

: 152455-76-0
8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone

Guidance literature:: With piperidine; In ethanol; for 1h; Heating;
DOI:10.1021/ja00076a035

Reference yield:

: 99573-20-3
2-Amino-3-(benzyloxy)-4-bromobenzaldehyde

: 152455-76-0
8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH / methanol / 6 h / 57 °C

2: HCl / 5 h / 24 °C

3: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min

4: 81 percent / piperidine / ethanol / 1 h / Heating

With piperidine; hydrogenchloride; sodium hydroxide; lithium diisopropyl amide; In methanol; ethanol;
DOI:10.1021/ja00076a035

Reference yield:

: 495409-83-1
8-benzyloxy-7-bromo-quinoline-2-carboxylic acid

: 152455-76-0
8-(benzyloxy)-7-bromoquinolin-2-yl 7,8-dimethoxy-2-oxo-2H-1-benzopyran-3-yl ketone

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / 5 h / 24 °C

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min

3: 81 percent / piperidine / ethanol / 1 h / Heating

With piperidine; hydrogenchloride; lithium diisopropyl amide; In ethanol;
DOI:10.1021/ja00076a035