4-ethoxycarbonyl-2-(2-phenylquinolin-4-yl)pyridine N-oxide

Base Information

• Chemical Name: 4-ethoxycarbonyl-2-(2-phenylquinolin-4-yl)pyridine N-oxide
• CAS No.: 1286763-45-8
• Molecular Formula: C₂₃H₁₈N₂O₃
• Molecular Weight: 370.408
• Mol file: 1286763-45-8.mol

Synonyms:4-ethoxycarbonyl-2-(2-phenylquinolin-4-yl)pyridine N-oxide

Chemical Property of 4-ethoxycarbonyl-2-(2-phenylquinolin-4-yl)pyridine N-oxide

Chemical Property:

Purity/Quality:

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Technology Process of 4-ethoxycarbonyl-2-(2-phenylquinolin-4-yl)pyridine N-oxide

There total 2 articles about 4-ethoxycarbonyl-2-(2-phenylquinolin-4-yl)pyridine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

ethyl isonicotinate N-oxide (14906-37-7) + 4-chloro-2-phenylquinoline (4979-79-7) → 4-ethoxycarbonyl-2-(2-phenylquinolin-4-yl)pyridine N-oxide (1286763-45-8)

Guidance literature:

With tri-tert-butyl phosphine; palladium diacetate; potassium carbonate; In toluene; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol200565u

Reference yield:

isonicotinic acid ethylester (1570-45-2) → 4-ethoxycarbonyl-2-(2-phenylquinolin-4-yl)pyridine N-oxide (1286763-45-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dihydrogen peroxide / acetic acid / 70 °C / Inert atmosphere

2: tri-tert-butyl phosphine; palladium diacetate; potassium carbonate / toluene / 24 h / 120 °C / Inert atmosphere

With tri-tert-butyl phosphine; dihydrogen peroxide; palladium diacetate; potassium carbonate; In acetic acid; toluene;

DOI:10.1021/ol200565u

upstream raw materials:

isonicotinic acid ethylester

ethyl isonicotinate N-oxide

4-chloro-2-phenylquinoline

Refernces