Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 415684-05-8
• Molecular Formula: C8H16 Cl N O3
• Molecular Weight: 209.673
• Mol file: 415684-05-8.mol

Synonyms:Carbamicacid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI); (S)-N-(3-Chloro-2-hydroxypropyl)carbamatetert-butyl ester; tert-Butyl [(2S)-3-chloro-2-hydroxypropyl]carbamate;tert-Butyl [(2S)-3-chloro-2-hydroxypropyl]carbamate

Chemical Property of Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 58.56000
• LogP: 1.50170

Purity/Quality:

98% ^*data from raw suppliers

(S)-tert-Butyl(3-chloro-2-hydroxypropyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI)

There total 4 articles about Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

di-tert-butyl dicarbonate (24424-99-5) + (2S)-1-amino-3-chloropropan-2-ol hydrogen chloride (34839-13-9,54798-66-2) → tert-butyl (2S)-3-chloro-2-hydroxypropylcarbamate (415684-05-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield: 71.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-1-amino-3-chloro-2-propanol hydrochloride (34839-13-9,54798-66-2) → tert-butyl (2S)-3-chloro-2-hydroxypropylcarbamate (415684-05-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h; Cooling with ice;

Reference yield: 71.0%

di-tert-butyl dicarbonate (24424-99-5) + (2S)-1-azido-3-chloropropan-2-ol (681225-50-3) → tert-butyl (2S)-3-chloro-2-hydroxypropylcarbamate (415684-05-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; at 20 ℃; for 12h;

DOI:10.1016/j.tetlet.2008.03.061

upstream raw materials:

di-tert-butyl dicarbonate

(2S)-1-amino-3-chloropropan-2-ol hydrogen chloride

(2S)-1-azido-3-chloropropan-2-ol

(S)-1-amino-3-chloro-2-propanol hydrochloride

Downstream raw materials:

(S)-[[3-[4-(2,3-dihydro-1,1-dioxido-4H-1,4-thiazin-4-yl)-3,5-difluorophenyl]-2-oxo-5-oxazolidinyl]methyl]carbamic acid, 1,1-dimethylethyl ester

(3-{4-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-3-fluoro-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-carbamic acid tert-butyl ester

(S)-<<(tert-butoxycarbonyl)amino>methyl>oxirane

tert-butyl {(5S)-3-[3,5-difluoro-4-(3-hydroxy-3-methylcyclobutyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate

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