cis-3-(3-methoxyphenyl)-5-<(methylmercapto)methyl>-N-n-propylpiperidine

Base Information

Chemical Name:cis-3-(3-methoxyphenyl)-5-<(methylmercapto)methyl>-N-n-propylpiperidine
CAS No.:97000-29-8
Molecular Formula:C₁₇H₂₇NOS
Molecular Weight:293.473
Hs Code.:

Synonyms:cis-3-(3-methoxyphenyl)-5-<(methylmercapto)methyl>-N-n-propylpiperidine

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Chemical Property of cis-3-(3-methoxyphenyl)-5-<(methylmercapto)methyl>-N-n-propylpiperidine

Chemical Property:

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Technology Process of cis-3-(3-methoxyphenyl)-5-<(methylmercapto)methyl>-N-n-propylpiperidine

There total 12 articles about cis-3-(3-methoxyphenyl)-5-<(methylmercapto)methyl>-N-n-propylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37669-64-0
(5-bromopyridin-3-yl)methanol

: 97000-29-8
cis-3-(3-methoxyphenyl)-5-<(methylmercapto)methyl>-N-n-propylpiperidine

Guidance literature:: Multi-step reaction with 8 steps

1: N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride / 1.) RT, 2.) 25 deg C, 1 h

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / Heating

3: hydrogenchloride; potassium permanganate / 1.) H₂O, 1 h, 2.) overnight

4: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 6 h / 2585.7 Torr

5: triethylamine / tetrachloromethane / 3 h / 0 - 20 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / Ambient temperature

7: triethylamine / tetrahydrofuran / 0.08 h

8: triethylamine / tetrahydrofuran; ethanol; water / 1 h / 55 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium permanganate; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium hydride; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; water;
DOI:10.1021/jm00147a046

Reference yield:

: 36282-40-3
(3-methoxyphenyl)magnesium bromide

: 97000-29-8
cis-3-(3-methoxyphenyl)-5-<(methylmercapto)methyl>-N-n-propylpiperidine

Guidance literature:: Multi-step reaction with 7 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / Heating

2: hydrogenchloride; potassium permanganate / 1.) H₂O, 1 h, 2.) overnight

3: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 6 h / 2585.7 Torr

4: triethylamine / tetrachloromethane / 3 h / 0 - 20 °C

5: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / Ambient temperature

6: triethylamine / tetrahydrofuran / 0.08 h

7: triethylamine / tetrahydrofuran; ethanol; water / 1 h / 55 °C

With hydrogenchloride; potassium permanganate; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; water;
DOI:10.1021/jm00147a046

Reference yield:

: 20260-53-1
pyridine-3-carbonyl chloride hydrochloride

: 97000-29-8
cis-3-(3-methoxyphenyl)-5-<(methylmercapto)methyl>-N-n-propylpiperidine

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) Br₂, 2.) NaBH₄ / 1.) reflux, 18 h, 2.) EtOH, from -10 to 0 deg C

2: 1.) NaH, HMPA / 1.) RT, 2.) 25 deg C, 1 h

3: tetrakis(triphenylphosphine)palladium / tetrahydrofuran / 1.5 h / Heating

4: 1.) KMnO₄, 2.) HCl gas / 1.) H₂O, 1 h, 2.) overnight

5: H₂, conc. HCl / PtO₂ / methanol / 6 h / 2585.7 Torr

6: triethylamine / CCl₄ / 3 h / 0 - 20 °C

7: LiAlH₄ / tetrahydrofuran / 18 h / Ambient temperature

8: triethylamine / tetrahydrofuran / 0.08 h

9: triethylamine / tetrahydrofuran; ethanol; H₂O / 1 h / 55 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; potassium permanganate; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; bromine; sodium hydride; triethylamine; platinum(IV) oxide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; water;
DOI:10.1021/jm00147a046