N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Base Information

Chemical Name:N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide
CAS No.:1033765-97-7
Molecular Formula:C₂₃H₂₄FN₅O₆S₂
Molecular Weight:549.604
Hs Code.:

N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Synonyms:N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

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Chemical Property of N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

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Technology Process of N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

There total 12 articles about N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1033766-16-3
1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester

: 1033765-97-7
N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Guidance literature:: 1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester; With sodium ethanolate; In ethanol; at 25 - 60 ℃; for 5h;

With hydrogenchloride; In ethanol; water;

Reference yield:

: 1000313-20-1
(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid

: 459-57-4
4-fluorobenzaldehyde

: 1033765-97-7
N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Guidance literature:: pyrrolidine-2-carboxylic acid ester; With 1-oxa-2-azaspiro[2.5]octane; In toluene; at 80 ℃; for 16h;

4-fluorobenzaldehyde; In methanol; at 45 ℃;

(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid; Further stages;
DOI:10.1016/j.bmcl.2008.08.017

Reference yield:

: 96-72-0
2-chloro-5-nitrobenzenesulfonamide

: 1033765-97-7
N-{3-[1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,8-hexahydro-1H-pyrido[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonia; ammonium carbonate / copper(II) sulfide / water / 4 h / 120 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 26 h / 25 °C / 760.05 Torr

3.1: pyridine / acetonitrile / 16 h / 25 °C

4.1: diethyl ether; N,N-dimethyl acetamide / 1 h / 25 °C

5.1: sodium hydroxide / water / 1.5 h / 100 °C

5.2: 0 °C / pH 1 - 2

6.1: dicyclohexyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 2 h

7.1: sodium ethanolate / ethanol / 5 h / 25 - 60 °C

With pyridine; sodium hydroxide; ammonia; hydrogen; sodium ethanolate; ammonium carbonate; dicyclohexyl-carbodiimide; palladium 10% on activated carbon; copper(II) sulfide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile;