1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester

Base Information

Chemical Name:1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester
CAS No.:1033766-16-3
Molecular Formula:C₂₅H₃₀FN₅O₇S₂
Molecular Weight:595.673
Hs Code.:

1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester

Synonyms:1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester

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Chemical Property of 1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester

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Technology Process of 1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester

There total 10 articles about 1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000313-20-1
(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid

: 1033766-15-2
1-(4-fluorobenzylamino)piperidine-2-carboxylic acid ethyl ester

: 1033766-16-3
1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 2h;

Reference yield:

: 96-72-0
2-chloro-5-nitrobenzenesulfonamide

: 1033766-16-3
1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia; ammonium carbonate / copper(II) sulfide / water / 4 h / 120 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 26 h / 25 °C / 760.05 Torr

3.1: pyridine / acetonitrile / 16 h / 25 °C

4.1: diethyl ether; N,N-dimethyl acetamide / 1 h / 25 °C

5.1: sodium hydroxide / water / 1.5 h / 100 °C

5.2: 0 °C / pH 1 - 2

6.1: dicyclohexyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 2 h

With pyridine; sodium hydroxide; ammonia; hydrogen; ammonium carbonate; dicyclohexyl-carbodiimide; palladium 10% on activated carbon; copper(II) sulfide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 96-73-1
2-chloro-5-nitro-benzenesulfonic acid

: 1033766-16-3
1-{(4-fluorobenzyl)[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1;λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}piperidine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Heating / reflux

2.1: ammonia / tetrahydrofuran; water; toluene / 2 h / -10 °C

2.2: pH 4

3.1: ammonia; ammonium carbonate / copper(II) sulfide / water / 4 h / 120 °C

4.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 26 h / 25 °C / 760.05 Torr

5.1: pyridine / acetonitrile / 16 h / 25 °C

6.1: diethyl ether; N,N-dimethyl acetamide / 1 h / 25 °C

7.1: sodium hydroxide / water / 1.5 h / 100 °C

7.2: 0 °C / pH 1 - 2

8.1: dicyclohexyl-carbodiimide / dichloromethane; N,N-dimethyl-formamide / 2 h

With pyridine; sodium hydroxide; thionyl chloride; ammonia; hydrogen; ammonium carbonate; dicyclohexyl-carbodiimide; palladium 10% on activated carbon; copper(II) sulfide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene; acetonitrile;