N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline

Base Information

Chemical Name:N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline
CAS No.:1431385-70-4
Molecular Formula:C₁₈H₁₅F₄N₃
Molecular Weight:349.331
Hs Code.:

Synonyms:N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline

Chemical Property:

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Technology Process of N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline

There total 5 articles about N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.7%

: 1431386-43-4
C₁₈H₁₃F₄N₃O

: 1431385-70-4
N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline

Guidance literature:: With borane-THF; In tetrahydrofuran; at 50 ℃; for 5h;

Reference yield:

: 33468-67-6
2-methyl-4-(trifluoromethyl)-1H-imidazole

: 1431385-70-4
N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 120 °C

1.2: 3 h / 120 °C

2.1: stannous chloride dehydrate / N,N-dimethyl-formamide; ethyl acetate / 50 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 5 h / 50 °C

With borane-THF; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 362613-64-7
C₁₁H₈F₃N₃O₂

: 1431385-70-4
N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: stannous chloride dehydrate / N,N-dimethyl-formamide; ethyl acetate / 50 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

3: borane-THF / tetrahydrofuran / 5 h / 50 °C

With borane-THF; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;