33468-67-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-4-trifluoromethylimidazole is used as a catalyst in organic synthesis reactions for its strong basic properties, facilitating the production of various pharmaceuticals.
Used in Agrochemical Industry:
2-Methyl-4-trifluoromethylimidazole is used as a building block in the synthesis of agrochemicals, contributing to the development of effective and efficient products for agricultural applications.
Used in Dye Industry:
2-Methyl-4-trifluoromethylimidazole is used as a key intermediate in the production of dyes, enhancing the color properties and performance of the final products.

InChI:InChI=1/C5H5F3N2/c1-3-9-2-4(10-3)5(6,7)8/h2H,1H3,(H,9,10)

Upstream product

• 75-07-0 acetaldehyde 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 
• 693-98-1 2-methylimidazole 
• 2926-29-6 Langlois reagent 
• 91944-47-7 3,3,3-Trifluoropyruvaldehyde 
• 2314-97-8 iodotrifluoromethane 
• 1184-76-5 difluorodiiodomethane 

Downstream Products

• 1415640-60-6 N-(2,6-difluorobenzyl)-5-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)pyridin-2-amine 
• 1415640-59-3 (2,6-difluorophenyl)-N-{5-[2-methyl-4-(trifluoromethyl)imidazolyl](2-pyridyl)}carboxamide 
• 1431386-79-6 C₁₁H₉F₄N₃ 
• 1431386-38-7 C₁₈H₁₂F₅N₃O 
• 1431385-65-7 3-fluoro-N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline 
• 1431386-80-9 C₁₁H₁₀F₃N₃ 
• 1431386-43-4 C₁₈H₁₃F₄N₃O 
• 1431385-70-4 N-(2-fluorobenzyl)-4-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)aniline 
• 1431386-78-5 C₁₁H₇F₄N₃O₂ 
• 362613-64-7 C₁₁H₈F₃N₃O₂ 
• 112108-86-8 2-methyl-1H-imidazole-4-carbonitrile 
• 1613395-28-0 1-[1-(4-chlorophenyl)-5-isopropylpyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluoroacetate 
• 1613394-86-7 1-[1-(4-fluorophenyl)-5-methylpyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one 
• 1613395-12-2 1-[1-(4-fluorophenyl)-5-isopropoxypyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one 

Relevant academic research and scientific papers

CATALYST-FREE AND REDOX-NEUTRAL INNATE TRIFLUOROMETHYLATION AND ALKYLATION OF (HETERO)AROMATICS ENABLED BY LIGHT

The present disclosure relates to reagents and method for performing trifluoromethylation, difluoromethylation or alkylation of aromatic or heteroaromatic rings in a redox-neutral manner without any catalyst which are enabled by light. In addition, there are methods for synthesizing the starting reagents used in the trifluoromethylation, difluoromethylation or alkylation reactions.

Catalyst-Free and Redox-Neutral Innate Trifluoromethylation and Alkylation of Aromatics Enabled by Light

The Minisci alkylation is useful to functionalize aromatics via alkyl radical addition. Current approaches to prepare alkyl radicals follow either oxidative or reductive pathways from various functional groups. Developing new strategy beyond these traditional methods remains elusive yet highly significant. In this article, we present a redox-neutral and catalyst-free protocol to engender alkyl radicals in the context of trifluoromethylation and general alkylation of arenes. This protocol, via the Norrish type I concept to produce alkyl radicals, accommodates various functional groups and delivers the product in good yields. This method identified a series of compounds as the trifluoromethylation and alkylation reagents assisted by light. It is expected that these compounds can find potential applications in other radical-involved reactions.

Simple and Clean Photoinduced Aromatic Trifluoromethylation Reaction

We describe a simple, metal-and oxidant-free photochemical strategy for the direct trifluoromethylation of unactivated arenes and heteroarenes under either ultraviolet or visible light irradiation. We demonstrated that photoexcited aliphatic ketones, such as acetone and diacetyl, can be used as promising low-cost radical initiators to generate CF3 radicals from sodium triflinate efficiently. The broad utility of this strategy and its benefit to medicinal chemistry are demonstrated by the direct trifluoromethylation of unprotected bidentate chelating ligand, xanthine alkaloids, nucleosides, and related antiviral drug molecules.

HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

SULPHUR-LINKED IMIDAZOLE COMPOUNDS FOR THE TREAMENT OF HIV

This invention relates to isophthalonitrile derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereof, wherein R1 to R3 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives.The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof.

Photoinduced Electron-transfer Reaction of Difluorodiiodomethane with Azaaromatic Compounds and Enamines

Irradiation of difluorodiiodomethane 1 with pyrroles, indole and imidazoles in dimethylformamide gives the corresponding trifluoromethylated products, whereas irradiation with enamines results in 2-trifluoromethyl ketones.A photoinduced electron-transfer mechanism is proposed.

Photochemical Perfluoroalkylation of Imidazoles

Imidazole and its derivatives undergo facile trifluoromethylation or perfluoroalkylation, in methanol solution at ambient temperature, following radical dissociation of RFI by γ or UV irradiation.In the case of imidazole, attack occurs preferen

Trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni

2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni