(R)-benzyl 4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carboxylate

Base Information

Chemical Name:(R)-benzyl 4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carboxylate
CAS No.:1448219-24-6
Molecular Formula:C₂₂H₃₂N₂O₄
Molecular Weight:388.507
Hs Code.:

Synonyms:(R)-benzyl 4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carboxylate

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Chemical Property of (R)-benzyl 4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carboxylate

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Technology Process of (R)-benzyl 4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carboxylate

There total 1 articles about (R)-benzyl 4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 885275-00-3
4-iodo-piperidine-1-carboxylic acid benzyl ester

: 86953-79-9
tert-butyl pyrrolidine-1-carboxylate

: 1448219-24-6
(R)-benzyl 4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carboxylate

Guidance literature:: tert-butyl pyrrolidine-1-carboxylate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at -78 ℃; for 3.5h; Inert atmosphere;

With zinc(II) iodide; In tetrahydrofuran; diethyl ether; cyclohexane; at -78 - 20 ℃; for 1.5h; Cooling with acetone-dry ice; Inert atmosphere;

4-iodo-piperidine-1-carboxylic acid benzyl ester; With (1,2-dimethoxyethane)dichloronickel(II); (1R,2R)-N,N’-dimethyl-1,2-di(naphthalen-1-yl)ethane-1,2-diamine; In tetrahydrofuran; diethyl ether; cyclohexane; at 20 ℃; for 60h; Reagent/catalyst; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja4054114

Reference yield:

: 1448219-24-6
(R)-benzyl 4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carboxylate

: C₁₇H₂₄N₂O₂

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;
DOI:10.1021/ja4054114

Reference yield:

: 1448219-24-6
(R)-benzyl 4-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)piperidine-1-carboxylate

: C₂₄H₃₀N₂O₄S

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h

2: triethylamine / dichloromethane / 10 h

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja4054114