(R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Base Information

Chemical Name:(R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate
CAS No.:1346786-92-2
Molecular Formula:C₁₉H₁₇BrN₂O₄S
Molecular Weight:449.325
Hs Code.:

Synonyms:(R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

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Chemical Property of (R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

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Technology Process of (R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

There total 2 articles about (R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 81075-61-8
(R)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1346786-92-2
(R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2011.09.020

Reference yield:

: 72002-54-1
(3R)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid

: 1346786-92-2
(R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / 0 - 20 °C

2: triethylamine / dichloromethane / 20 °C

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1016/j.bmc.2011.09.020

Reference yield:

: 1346786-92-2
(R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

: 1346786-99-9
(S)-2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

: 1346787-03-8
(R)-2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Guidance literature:: (R)-methyl 2-(4-bromophenylsulfonyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With acetic acid; In water;
DOI:10.1016/j.bmc.2011.09.020