1-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-ethylurea

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Chemical Name:1-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-ethylurea
CAS No.:1337930-75-2
Molecular Formula:C₂₉H₃₁Cl₂N₇O₄
Molecular Weight:612.516
Hs Code.:

Synonyms:1-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-ethylurea

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Chemical Property of 1-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-ethylurea

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Technology Process of 1-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-ethylurea

There total 5 articles about 1-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-ethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1337932-06-5
1-(4-((2-aminopyridin-4-yl)oxy)-2,3-dichlorophenyl)-3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)urea

: 109-90-0
ethyl isocyanate

: 1337930-75-2
1-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-ethylurea

Guidance literature:: 1-(4-((2-aminopyridin-4-yl)oxy)-2,3-dichlorophenyl)-3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)urea; ethyl isocyanate; In pyridine; at 0 - 35 ℃; for 48h; Inert atmosphere;

With ammonia; In pyridine; methanol; for 1h;

Reference yield:

: 33631-05-9
2-amino-4-hydroxypyridine

: 1337930-75-2
1-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-ethylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: acetic acid; iron / 1 h / 60 °C

2.2: 20 °C

3.1: dichloromethane / 1.67 h / 20 °C

3.2: 6 h

4.1: pyridine / 48 h / 0 - 35 °C / Inert atmosphere

4.2: 1 h

With iron; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; dichloromethane; acetonitrile;

Reference yield:

: 36556-51-1
2,3-dichloro-1-fluoro-4-nitrobenzene

: 1337930-75-2
1-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyridin-2-yl)-3-ethylurea

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: acetic acid; iron / 1 h / 60 °C

2.2: 20 °C

3.1: dichloromethane / 1.67 h / 20 °C

3.2: 6 h

4.1: pyridine / 48 h / 0 - 35 °C / Inert atmosphere

4.2: 1 h

With iron; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In pyridine; dichloromethane; acetonitrile;