2-Aminopyridin-4-ol

Base Information

• Chemical Name: 2-Aminopyridin-4-ol
• CAS No.: 33631-05-9
• Molecular Formula: C5H6N2O
• Molecular Weight: 110.115
• Hs Code.: 2933399090
• Mol file: 33631-05-9.mol

Synonyms:2-Amino-4-pyridinol;4-Hydroxypyridin-2-amine;

Chemical Property of 2-Aminopyridin-4-ol

Chemical Property:

• Vapor Pressure: 0.0178mmHg at 25°C
• Melting Point: 85 °C
• Refractive Index: 1.555
• Boiling Point: 253.9 °C at 760 mmHg
• PKA: 5.30±0.18(Predicted)
• Flash Point: 107.4 °C
• PSA: 59.14000
• Density: 1.208 g/cm³
• LogP: 0.95060
• Storage Temp.: Room temperature.
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-hydroxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field

Technology Process of 2-Aminopyridin-4-ol

There total 4 articles about 2-Aminopyridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-amino-4-methoxypyridine (10201-73-7) → 2-amino-4-hydroxypyridine (33631-05-9)

Guidance literature:

With L-Selectride; In tetrahydrofuran; for 72h; chemoselective reaction; Reflux; Inert atmosphere;

DOI:10.1055/s-0037-1612427

Reference yield: 57.0%

2-Amino-4-chloropyridine (19798-80-2) → 2-amino-4-hydroxypyridine (33631-05-9)

Guidance literature:

With potassium hydroxide; In water; at 160 ℃; for 27h;

DOI:10.1021/jm900564x

Reference yield:

4-chloro-2-pyridinylisocyanate (1026394-00-2) → 2-amino-4-hydroxypyridine (33631-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 6 M aq. HCl / 48 h / Heating

2: 3 M aq. NaOH / 20 h / 180 °C

With hydrogenchloride; sodium hydroxide;

DOI:10.1080/00304949709355174

upstream raw materials:

2-Amino-4-chloropyridine

4-chloro-2-pyridinylisocyanate

2-amino-4-methoxypyridine

Downstream raw materials:

7-(2-methyl-4-nitrophenoxy)imidazo [1,2-a]pyridine

4-(imidazo[1,2-a]pyridin-7-yloxy)-3-methylaniline

4-(2-methyl-4-nitrophenoxy)pyridin-2-amine

2-phenyl-7-(N,N-dimethylcarbamoyloxy)imidazo[1,2-a]pyridine

Refernces

• 1、 Porwal, Sharad,Chauhan, Shikha S.,Chauhan, Prem M. S.,Shakya, Nishi,Verma, Aditya,Gupta, Suman. "Discovery of novel antileishmanial agents in an attempt to synthesize pentamidine - Aplysinopsin hybrid molecule". supporting information; experimental part. p. 5793 - 5802. Retrieved 2010/03/24.
• 2、 -. "CNS active compounds". . . Retrieved 2008/06/13.