2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionitrile

Base Information

Chemical Name:2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionitrile
CAS No.:1157580-33-0
Molecular Formula:C₂₈H₃₂N₂
Molecular Weight:396.575
Hs Code.:

Synonyms:2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionitrile

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Chemical Property of 2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionitrile

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Technology Process of 2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionitrile

There total 1 articles about 2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 930-68-7
cyclohexenone

: 850568-67-1
[4-(1-cyano-1-methylethyl)phenyl]boronic acid

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: 1157580-33-0
2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionitrile

Guidance literature:: cyclohexenone; [4-(1-cyano-1-methylethyl)phenyl]boronic acid; lithium hydroxide; [(1,4-hydroquinone)-rhodium(COD)]BF₄; In 1,2-dimethoxyethane; water; at 50 ℃;

(R)-1-(1-Naphthyl)ethylamine; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 1157580-33-0
2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionitrile

: 1157580-34-1
2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionic acid

Guidance literature:: 2-methyl-2-{4-[3-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-phenyl}-propionitrile; With sodium hydroxide; water; In methanol; for 72h; Heating / reflux;

With hydrogenchloride; In water; pH=5;