3β-(6-aminopurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane

Base Information

Chemical Name:3β-(6-aminopurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane
CAS No.:869710-87-2
Molecular Formula:C₂₁H₂₄FN₅O₃
Molecular Weight:413.452
Hs Code.:

Synonyms:3β-(6-aminopurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane

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Chemical Property of 3β-(6-aminopurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane

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Technology Process of 3β-(6-aminopurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane

There total 5 articles about 3β-(6-aminopurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 869711-07-9
3β-(6-chloropurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane

: 869710-87-2
3β-(6-aminopurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane

Guidance literature:: With ammonia; In methanol;
DOI:10.1016/j.tetlet.2005.08.163

Reference yield:

: 869792-62-1
3β-azido-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane

: 869710-87-2
3β-(6-aminopurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Lindlar catalyst / methanol

2: Et₃N / butan-1-ol / 105 °C

3: Heating

4: 69 percent / NH₃ / methanol

With ammonia; hydrogen; triethylamine; Lindlar's catalyst; In methanol; butan-1-ol;
DOI:10.1016/j.tetlet.2005.08.163

Reference yield:

: 100101-50-6
<1S-(1α,2β,3α,4α,5β)>-2-azido-3,4-(dimethylmethylenedioxy)-5-<(phenylmethoxy)methyl>-1-cyclopentanol

: 869710-87-2
3β-(6-aminopurin-9-yl)-4β-fluoro-5β-benzyloxymethyl-1α,2α-isopropylidenedioxycyclopentane

Guidance literature:: Multi-step reaction with 5 steps

1.1: Tf₂O / pyridine; CH₂Cl₂

1.2: 85 percent / TASF / tetrahydrofuran

2.1: H₂ / Lindlar catalyst / methanol

3.1: Et₃N / butan-1-ol / 105 °C

4.1: Heating

5.1: 69 percent / NH₃ / methanol

With trifluoromethylsulfonic anhydride; ammonia; hydrogen; triethylamine; Lindlar's catalyst; In pyridine; methanol; dichloromethane; butan-1-ol;
DOI:10.1016/j.tetlet.2005.08.163