[2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-pyrrolidin-1-yl-amine

Base Information

• Chemical Name: [2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-pyrrolidin-1-yl-amine
• CAS No.: 255724-89-1
• Molecular Formula: C₂₁H₂₃F₃N₂O
• Molecular Weight: 376.422

Synonyms:[2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-pyrrolidin-1-yl-amine

Chemical Property of [2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-pyrrolidin-1-yl-amine

Chemical Property:

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Technology Process of [2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-pyrrolidin-1-yl-amine

There total 2 articles about [2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-pyrrolidin-1-yl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzyl bromide (100-39-0) + 1,1,1-Trifluoro-3-phenyl-2-[(E)-pyrrolidin-1-yliminomethyl]-propan-2-ol (220955-85-1) → [2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-pyrrolidin-1-yl-amine (255724-89-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

DOI:10.1021/jo991049u

Reference yield:

formaldehyde N,N-tetramethylenehydrazone (60144-26-5) → [2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-pyrrolidin-1-yl-amine (255724-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / CH₂Cl₂ / 1.25 h / 20 °C

2: 89 percent / NaH / dimethylformamide / 1.5 h / 20 °C

With sodium hydride; In dichloromethane; N,N-dimethyl-formamide; 1: Addition / 2: benzylation;

DOI:10.1021/jo991049u

Reference yield: 86.0%

[2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-pyrrolidin-1-yl-amine (255724-89-1) → 2-benzyl-2-benzyloxy-3,3,3-trifluoro-propionitrile

Guidance literature:

With magnesium monoperoxyphthalate hexahydrate; In methanol; at 0 ℃; for 0.75h;

DOI:10.1021/jo991049u

upstream raw materials:

benzyl bromide

1,1,1-Trifluoro-3-phenyl-2-[(E)-pyrrolidin-1-yliminomethyl]-propan-2-ol

formaldehyde N,N-tetramethylenehydrazone

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