(3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Base Information

Chemical Name:(3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one
CAS No.:101566-47-6
Molecular Formula:C₁₈H₂₅NO₂
Molecular Weight:287.402
Hs Code.:

Synonyms:(3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

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Chemical Property of (3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Chemical Property:

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Technology Process of (3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

There total 1 articles about (3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101566-46-5,101692-75-5
(3S,7aR)-3-Isopropyl-7a-methyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

: 74-88-4
methyl iodide

: 101566-47-6
(3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

: 101692-76-6
(3S,6R,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Guidance literature:: With sec.-butyllithium; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -100 deg C, 30 min, 2.) THF, 1 h;
DOI:10.1021/jo00359a030

Reference yield: 100.0%

: 101566-47-6
(3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

: 101566-48-7
(3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-hexahydro-pyrrolo[2,1-b]oxazol-5-ol

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at -20 ℃; for 20h;
DOI:10.1021/jo00359a030

Reference yield:

: 101566-47-6
(3S,6S,7aR)-3-Isopropyl-6,7a-dimethyl-6-p-tolyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

: 101693-57-6
(R)-(+)-4-methyl-4-(4-methylphenyl)cyclopent-2-enone

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Red-Al / toluene / 20 h / -20 °C

2: 98 percent / Bu₄NH₂PO₄ / ethanol; H₂O / 12 h / Ambient temperature

3: 90 percent / KOH / tetrahydrofuran; ethanol / 1 h / Ambient temperature

With potassium hydroxide; tetrabutylammonium dihydrogen phosphate; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/jo00359a030