2,3-Dihydroxy-2-methylpropanoic acid

Base Information

• Chemical Name: 2,3-Dihydroxy-2-methylpropanoic acid
• CAS No.: 21620-60-0
• Molecular Formula: C4H8 O4
• Molecular Weight: 120.105
• Hs Code.: 2918290000
• European Community (EC) Number: 833-648-5
• DSSTox Substance ID: DTXSID70865002
• Nikkaji Number: J235.964B
• Wikidata: Q27116873
• Metabolomics Workbench ID: 1516
• Mol file: 21620-60-0.mol

Synonyms:2,3-dihydroxy-2-methylpropanoic acid;21620-60-0;2-methylglyceric acid;Propanoic acid, 2,3-dihydroxy-2-methyl-;2,3-dihydroxy-2-methylpropionic acid;A,b-Dihydroxyisobutyric acid;2,3-DIHYDROXY-2-METHYL-PROPANOIC ACID;Propanoic acid, 2,3- dihydroxy-2-methyl-;2-C-methylglyceric acid;alpha-methylglyceric acid;a,b-dihydroxy-isobutyric acid;2,3-dihydroxy-2-methyl-propionic acid;2,3-dihydroxy-2-methylpropionate;a-methylglycerate;2-methylglycerate;alpha,beta-dihydroxyisobutyric acid;2-methylglyceronate;alpha-methylglycerate;2-C-methylglycerate;a-methylglyceric acid;2-methylglyceronic acid;a,b-dihydroxyisobutyrate;SCHEMBL278725;CHEBI:36532;DTXSID70865002;2-methyl-2,3-dihydroxypropionate;2,3-dihydroxy-2-methyl-propanoate;2,3-dihydroxy-2-methylpropanoicacid;LMFA01050400;MFCD19228093;2-methyl-2,3-dihydroxypropionic acid;AKOS006377026;SB84354;2,3- Dihydroxy-2-methyl-propanoic acid;EN300-89418;Q27116873;Z1205493767

Chemical Property of 2,3-Dihydroxy-2-methylpropanoic acid

Chemical Property:

• Vapor Pressure: 1.36E-06mmHg at 25°C
• Melting Point: 104 °C
• Boiling Point: 358.8°Cat760mmHg
• PKA: 3.78±0.16(Predicted)
• Flash Point: 185°C
• PSA: 77.76000
• Density: 1.425g/cm³
• LogP: -1.18570
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: Methanol (Slightly, Sonicated), Water (Slightly)
• XLogP3: -1.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 120.04225873
• Heavy Atom Count: 8
• Complexity: 100

Purity/Quality:

99% ^*data from raw suppliers

α-MethylglycericAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CO)(C(=O)O)O
• Uses: α-Methylglyceric Acid is a biogenic secondary organic aerosol used in air quality diagnosis.

Technology Process of 2,3-Dihydroxy-2-methylpropanoic acid

There total 15 articles about 2,3-Dihydroxy-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydroxy-N-methoxy-2,N-dimethylpropionamide → 2-methylglyceric acid (21620-60-0)

Guidance literature:

With lithium hydroxide; In methanol; at 25 ℃; for 2h;

DOI:10.1039/b400282b

Reference yield:

poly(methacrylic acid) (79-41-4,25087-26-7,50867-57-7) → 2-methylglyceric acid (21620-60-0)

Guidance literature:

With dihydrogen peroxide; ortho-tungstic acid; at 80 ℃; for 2.25h; Yield given;

DOI:10.1055/s-1992-26087

Reference yield:

hydrogen cyanide (74-90-8) + β-oxopropyl formate (10258-70-5) → 2-methylglyceric acid (21620-60-0)

Guidance literature:

With water; potassium carbonate; durch Kochen des entstandenen Nitrils mit Salzsaeure;

upstream raw materials:

O⁴-methyl-D-threose

hydrogen cyanide

β-oxopropyl formate

2,3-dihydroxy-2-methyl-N-methylpropylamide

Downstream raw materials:

methyl 2,3-dihydroxy-2-methylpropanoate

2-hydroxy-2-methylpropanedioic acid

benzyl 2,2-dimethyl-3-hydroxypropanoic acid

4-chloro-carbonyl-4-methyl-1,3,2-dioxathiolane-2-one