2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester

Base Information

Chemical Name:2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester
CAS No.:1254367-88-8
Molecular Formula:C₅₀H₆₁FN₄O₁₁Si
Molecular Weight:941.138
Hs Code.:

2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester

Synonyms:2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester

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Chemical Property of 2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester

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Technology Process of 2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester

There total 14 articles about 2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 852821-06-8
(4aS,8aS,9S)-3-(benzyloxy)-4a-(tert-butyldimethylsilyloxy)-9-(dimethylamino)-8a,9-dihydronaphtho[2,3-d]isoxazole-4,5(4aH,8H)-dione

: 1254367-87-7
phenyl 3-benzyloxy-2-[bis(t-butoxycarbonyl)amino]-6-fluoro-5-methylisonicotinate

: 1254367-88-8
2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -10 ℃; for 2h;

Reference yield:

: 1254367-40-2
phenyl 3-(benzyloxy)-2,6-dibromo-5-methylisonicotinate

: 1254367-88-8
2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl carbazate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

2.1: pyridine; hydrogen fluoride; sodium nitrite / 0 - 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

4.1: dmap / N,N-dimethyl-formamide / 0.5 h

5.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine / tetrahydrofuran; hexane / 0.08 h / -78 °C

5.2: -78 - -20 °C

With pyridine; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tert-butyl carbazate; hydrogen fluoride; caesium carbonate; diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm1015389

Reference yield:

: 1254367-44-6
C₂₀H₁₆BrNO₄

: 1254367-88-8
2-[(4aS,11aR,12aS,13S)-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-10-fluoro-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[5',4':6,7]naphth[2,3-g]isoquinolin-8-yl]-imidodicarbonic acid, 1,3-bis(1,1-dimethylethyl) ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus(V) oxybromide / toluene / 0.75 h / 100 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl carbazate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

3.1: pyridine; hydrogen fluoride; sodium nitrite / 0 - 20 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

5.1: dmap / N,N-dimethyl-formamide / 0.5 h

6.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine; diisopropylamine / tetrahydrofuran; hexane / 0.08 h / -78 °C

6.2: -78 - -20 °C

With pyridine; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tert-butyl carbazate; hydrogen fluoride; caesium carbonate; diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium nitrite; phosphorus(V) oxybromide; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm1015389