Technology Process of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3-2,2',2'',2'''-{[4'-(4''-(5-hexyn-6-yl)phenyl)-2,2':6',2''-terpyridine-6,6''-diyl]bis(methylenenitrilo)}tetrakis(acetato)uridine
There total 10 articles about 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3-2,2',2'',2'''-{[4'-(4''-(5-hexyn-6-yl)phenyl)-2,2':6',2''-terpyridine-6,6''-diyl]bis(methylenenitrilo)}tetrakis(acetato)uridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
DOI:10.1021/ol016093m
- Guidance literature:
-
Multi-step reaction with 8 steps
1: I2
2: 45 percent / ammonium acetate / methanol / Heating
3: 85 percent / 3-chloroperbenzoic acid / CH2Cl2 / 20 °C
4: 77 percent / benzoyl chloride / CH2Cl2
5: BH3*THF / tetrahydrofuran / 2.5 h / cooling
6: 6.6 g / diisopropylethylamine; KI / dimethylformamide / 20 °C
7: 80 percent / CuI / Pd(Ph3P)2Cl2 / tetrahydrofuran; triethylamine / 60 °C
8: 61 percent / PPh3; DEAD / tetrahydrofuran / 2 h / 20 °C
With
ammonium acetate; copper(l) iodide; borane-THF; iodine; benzoyl chloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; potassium iodide; diethylazodicarboxylate;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; dichloromethane; triethylamine; N,N-dimethyl-formamide;
4: Reissert-Henze reaction / 8: Mitsunobu reaction;
DOI:10.1021/ol016093m
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 45 percent / ammonium acetate / methanol / Heating
2: 85 percent / 3-chloroperbenzoic acid / CH2Cl2 / 20 °C
3: 77 percent / benzoyl chloride / CH2Cl2
4: BH3*THF / tetrahydrofuran / 2.5 h / cooling
5: 6.6 g / diisopropylethylamine; KI / dimethylformamide / 20 °C
6: 80 percent / CuI / Pd(Ph3P)2Cl2 / tetrahydrofuran; triethylamine / 60 °C
7: 61 percent / PPh3; DEAD / tetrahydrofuran / 2 h / 20 °C
With
ammonium acetate; copper(l) iodide; borane-THF; benzoyl chloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; potassium iodide; diethylazodicarboxylate;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; methanol; dichloromethane; triethylamine; N,N-dimethyl-formamide;
3: Reissert-Henze reaction / 7: Mitsunobu reaction;
DOI:10.1021/ol016093m
