2-Pyrrolidinecarboxamide,3-hydroxy-,(2S,3S)-(9CI)

Base Information

• Chemical Name: 2-Pyrrolidinecarboxamide,3-hydroxy-,(2S,3S)-(9CI)
• CAS No.: 412279-18-6
• Molecular Formula: C5H10 N2 O2
• Molecular Weight: 130.147
• Mol file: 412279-18-6.mol

Synonyms:2-Pyrrolidinecarboxamide,3-hydroxy-,(2S,3S)-(9CI)

Chemical Property of 2-Pyrrolidinecarboxamide,3-hydroxy-,(2S,3S)-(9CI)

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(2S,3S)-3-Hydroxypyrrolidine-2-carboxamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinecarboxamide,3-hydroxy-,(2S,3S)-(9CI)

There total 4 articles about 2-Pyrrolidinecarboxamide,3-hydroxy-,(2S,3S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-3-hydroxy-L-proline (4298-08-2) → (2S,3S)-3-hydroxypyrrolidin-2-carboxamide (412279-18-6)

Guidance literature:

trans-3-hydroxy-L-proline; With hydrogenchloride; In 1,4-dioxane; ethanol; at 20 ℃; for 21h; Heating / reflux;

With ammonia; In methanol; at 20 ℃; for 48h;

Reference yield:

(2S,3S)-1-((benzyloxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid (62182-54-1) → (2S,3S)-3-hydroxypyrrolidin-2-carboxamide (412279-18-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Amberlyst 15 / Ambient temperature

2: H₂ / 10percent Pd/C / methanol / 1 h / Ambient temperature

3: 30percent aq. NH₃ / 48 h / Ambient temperature

With ammonium hydroxide; Amberlyst 15; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00021a013

Reference yield:

1-benzyl 2-methyl(2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylate → (2S,3S)-3-hydroxypyrrolidin-2-carboxamide (412279-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 1 h / Ambient temperature

2: 30percent aq. NH₃ / 48 h / Ambient temperature

With ammonium hydroxide; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00021a013

upstream raw materials:

methyl (2S,3S)-3-hydroxypyrrolidine-2-carboxylate

(2S,3S)-1-((benzyloxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

trans-3-hydroxy-L-proline

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