8-chloro-6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Name:8-chloro-6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one
CAS No.:1454580-56-3
Molecular Formula:C₁₉H₁₄ClFN₂O₃
Molecular Weight:372.783
Hs Code.:

Synonyms:8-chloro-6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one

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Chemical Property of 8-chloro-6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one

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Technology Process of 8-chloro-6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one

There total 4 articles about 8-chloro-6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1454580-54-1
8-chloro-6-[4-(4-fluorophenyl)-1-(4-methoxybenzyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one

: 1454580-56-3
8-chloro-6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: With methoxybenzene; trifluoroacetic acid; at 65 ℃; for 12h;
DOI:10.1016/j.bmc.2013.07.043

Reference yield:

: 1454580-50-7
ethyl N-[(4-fluorophenyl)acetyl]-N-(4-methoxybenzyl)alaninate

: 1454580-56-3
8-chloro-6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 3 h / 0 °C

3: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 12 h / 100 °C / Inert atmosphere

4: trifluoroacetic acid; methoxybenzene / 12 h / 65 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; caesium carbonate; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.07.043

Reference yield:

: 1454580-51-8
3-(4-fluorophenyl)-4-hydroxy-1-(4-methoxybenzyl)-5-methyl-1,5-dihydro-2H-pyrrol-2-one

: 1454580-56-3
8-chloro-6-[4-(4-fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-2H-1,4-benzoxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3 h / 0 °C

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 12 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid; methoxybenzene / 12 h / 65 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; methoxybenzene; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2013.07.043