2-[[2-propyl-3-[3-[2-ethyl-5-(phenylmethoxy)-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]-methyl]benzoic acid methyl ester

Base Information

Chemical Name:2-[[2-propyl-3-[3-[2-ethyl-5-(phenylmethoxy)-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]-methyl]benzoic acid methyl ester
CAS No.:152610-17-8
Molecular Formula:C₄₂H₄₃FO₅
Molecular Weight:646.799
Hs Code.:

Synonyms:2-[[2-propyl-3-[3-[2-ethyl-5-(phenylmethoxy)-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]-methyl]benzoic acid methyl ester

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Chemical Property of 2-[[2-propyl-3-[3-[2-ethyl-5-(phenylmethoxy)-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]-methyl]benzoic acid methyl ester

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Technology Process of 2-[[2-propyl-3-[3-[2-ethyl-5-(phenylmethoxy)-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]-methyl]benzoic acid methyl ester

There total 11 articles about 2-[[2-propyl-3-[3-[2-ethyl-5-(phenylmethoxy)-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]-methyl]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 152120-07-5
2-benzyloxy-1-(4-fluorophenyl)-5-ethyl-4-(3-chloro-1-propyloxy)benzene

: 152610-16-7
2-[(3-hydroxy-2-propylphenyl)-methyl]benzoic acid methyl ester

: 152610-17-8
2-[[2-propyl-3-[3-[2-ethyl-5-(phenylmethoxy)-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]-methyl]benzoic acid methyl ester

Guidance literature:: With potassium carbonate; dimethyl sulfoxide; potassium iodide; In butanone; for 18h; Heating;
DOI:10.1021/jm00022a006

Reference yield:

: 85-44-9
phthalic anhydride

: 152610-17-8
2-[[2-propyl-3-[3-[2-ethyl-5-(phenylmethoxy)-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]-methyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -70 deg C to RT

2: 100 percent / HCl(g) / 18 h / Ambient temperature

3: 54 percent / 30 h / 175 °C

4: 90 percent / H₂, conc. H₂SO₄ / 10percent Pd/C / methanol / Ambient temperature

5: 38 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

With hydrogenchloride; n-butyllithium; sulfuric acid; hydrogen; potassium carbonate; dimethyl sulfoxide; potassium iodide; palladium on activated charcoal; In methanol; butanone;
DOI:10.1021/jm00022a006

Reference yield:

: 41388-50-5
1-(allyloxy)-3-bromobenzene

: 152610-17-8
2-[[2-propyl-3-[3-[2-ethyl-5-(phenylmethoxy)-4-(4-fluorophenyl)phenoxy]propoxy]phenyl]-methyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -70 deg C to RT

2: 100 percent / HCl(g) / 18 h / Ambient temperature

3: 54 percent / 30 h / 175 °C

4: 90 percent / H₂, conc. H₂SO₄ / 10percent Pd/C / methanol / Ambient temperature

5: 38 percent / K₂CO₃, KI, DMSO / butan-2-one / 18 h / Heating

With hydrogenchloride; n-butyllithium; sulfuric acid; hydrogen; potassium carbonate; dimethyl sulfoxide; potassium iodide; palladium on activated charcoal; In methanol; butanone;
DOI:10.1021/jm00022a006