2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol

Base Information

Chemical Name:2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol
CAS No.:1257295-02-5
Molecular Formula:C₁₉H₂₉ClN₆O₂
Molecular Weight:408.931
Hs Code.:

Synonyms:2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol

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Chemical Property of 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol

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Technology Process of 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol

There total 2 articles about 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

: 22990-34-7
2-(piperidin-4-yl)propan-2-ol

: 1148003-33-1
2-chloro-9-methyl-6-morpholino-9H-purine-8-carbaldehyde

: 1257295-02-5
2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol

Guidance literature:: 2-(piperidin-4-yl)propan-2-ol; 2-chloro-9-methyl-6-morpholino-9H-purine-8-carbaldehyde; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 2h; Molecular sieve;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 2h; Molecular sieve;
DOI:10.1021/jm300717c

Reference yield: 78.0%

: 22990-34-7
2-(piperidin-4-yl)propan-2-ol

: 1257295-04-7
4-(8-(bromomethyl)-2-chloro-9-methyl-9H-purin-6-yl)morpholine

: 1257295-02-5
2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/jm300717c

Reference yield:

: 1257295-02-5
2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)-piperidin-4-yl)propan-2-ol

: 95-54-5
1,2-diamino-benzene

: 1257378-51-0
C₂₅H₃₆N₈O₂

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In N,N-dimethyl-formamide; at 140 ℃; for 0.666667h; Microwave irradiation;
DOI:10.1021/jm300717c