(1S,5R,7R)-5-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-7-endo-(hydroxymethyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane

Base Information

Chemical Name:(1S,5R,7R)-5-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-7-endo-(hydroxymethyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane
CAS No.:871702-83-9
Molecular Formula:C₂₉H₂₉NO₆
Molecular Weight:487.552
Hs Code.:

Synonyms:(1S,5R,7R)-5-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-7-endo-(hydroxymethyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane

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Chemical Property of (1S,5R,7R)-5-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-7-endo-(hydroxymethyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane

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Technology Process of (1S,5R,7R)-5-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-7-endo-(hydroxymethyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane

There total 6 articles about (1S,5R,7R)-5-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-7-endo-(hydroxymethyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 871702-82-8
3-benzyloxy-1-({[(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl](fluoren-9-ylmethoxycarbonyl)amino)propan-2-one

: 871702-83-9
(1S,5R,7R)-5-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-7-endo-(hydroxymethyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane

Guidance literature:: With methanol; trifluoroacetic acid; at 20 ℃; for 16h;
DOI:10.1002/ejoc.200500386

Reference yield:

: 871702-78-2
benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine

: 871702-83-9
(1S,5R,7R)-5-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-7-endo-(hydroxymethyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

2: 1.29 g / LiNTf₂ / CH₂Cl₂ / 12 h / 20 °C

3: 967 mg / Na₂CO₃*H₂O / dioxane; H₂O / 20 °C

4: 64 percent / (COCl)2; DMSO; DIPEA / CH₂Cl₂ / 2 h / -60 - 20 °C

5: 94 percent / TFA; MeOH / 16 h / 20 °C

With methanol; oxalyl dichloride; hydrogen; sodium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; bis(trifluoromethane)sulfonimide lithium; trifluoroacetic acid; palladium dihydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; 4: Swern reaction;
DOI:10.1002/ejoc.200500386

Reference yield:

: 603959-03-1
(4R,5S)-[5-(benzylaminomethyl)-2,2-dimethyl[1,3]dioxolan-4-yl]methanol

: 871702-83-9
(1S,5R,7R)-5-(benzyloxymethyl)-3-(fluoren-9-ylmethoxycarbonyl)-7-endo-(hydroxymethyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 6 steps

1: 72 percent / imidazole / CH₂Cl₂ / 2.5 h / 0 - 20 °C

2: 88 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

3: 1.29 g / LiNTf₂ / CH₂Cl₂ / 12 h / 20 °C

4: 967 mg / Na₂CO₃*H₂O / dioxane; H₂O / 20 °C

5: 64 percent / (COCl)2; DMSO; DIPEA / CH₂Cl₂ / 2 h / -60 - 20 °C

6: 94 percent / TFA; MeOH / 16 h / 20 °C

With 1H-imidazole; methanol; oxalyl dichloride; hydrogen; sodium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; bis(trifluoromethane)sulfonimide lithium; trifluoroacetic acid; palladium dihydroxide; In 1,4-dioxane; ethanol; dichloromethane; water; 5: Swern reaction;
DOI:10.1002/ejoc.200500386