benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine

Base Information

Chemical Name:benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine
CAS No.:871702-78-2
Molecular Formula:C₂₀H₃₅NO₃Si
Molecular Weight:365.588
Hs Code.:

Synonyms:benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine

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Technology Process of benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine

There total 1 articles about benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 603959-03-1
(4R,5S)-[5-(benzylaminomethyl)-2,2-dimethyl[1,3]dioxolan-4-yl]methanol

: 871702-78-2
benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine

Guidance literature:: With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 2.5h;
DOI:10.1002/ejoc.200500386

Reference yield:

: 871702-78-2
benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine

: 871702-81-7
3-benzyloxy-1-({[(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl](fluoren-9-ylmethoxycarbonyl)amino)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

2: 1.29 g / LiNTf₂ / CH₂Cl₂ / 12 h / 20 °C

3: 967 mg / Na₂CO₃*H₂O / dioxane; H₂O / 20 °C

With hydrogen; sodium carbonate; bis(trifluoromethane)sulfonimide lithium; palladium dihydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1002/ejoc.200500386

Reference yield:

: 871702-78-2
benzyl({(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl)amine

: 871702-80-6
1-benzyloxy-3-({[(4S,5R)-5-[(tert-butyldimethylsilyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methyl]amino)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / H₂ / Pd(OH)2/C / ethanol / 20 °C

2: 1.29 g / LiNTf₂ / CH₂Cl₂ / 12 h / 20 °C

With hydrogen; bis(trifluoromethane)sulfonimide lithium; palladium dihydroxide; In ethanol; dichloromethane;
DOI:10.1002/ejoc.200500386