(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride
CAS No.:1610859-87-4
Molecular Formula:C₃₃H₃₉Cl₂N₃O₉S*ClH
Molecular Weight:761.12
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride

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Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride

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Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride

There total 9 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 3240-94-6
N-(2-chlorethyl)morpholine

: 1610859-89-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide

: 1610859-87-4
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: N-(2-chlorethyl)morpholine; (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide; With potassium carbonate; In N,N-dimethyl-formamide; at 45 ℃;

With hydrogenchloride; In ethyl acetate;

Reference yield:

: 100868-46-0
3,5-dichloro-4-picoline

: 1610859-87-4
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: methanol; chloroform / 2 h / 20 °C

4.1: potassium tert-butylate; methanol / toluene / 24 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: N,N-dimethyl-formamide / 120 h / 100 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 45 °C

With methanol; dmap; potassium tert-butylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1610859-87-4
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(N-(2-morpholinoethyl)methylsulfonamido)benzoyloxy)-2-(3,4-dimethoxyphenyl)ethyl)pyridine 1-oxide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: methanol; chloroform / 2 h / 20 °C

4.1: potassium tert-butylate; methanol / toluene / 24 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: N,N-dimethyl-formamide / 120 h / 100 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 45 °C

With methanol; dmap; potassium tert-butylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;