N-{1-[4-(phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-acrylamide

Base Information

Chemical Name:N-{1-[4-(phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-acrylamide
CAS No.:1414967-42-2
Molecular Formula:C₂₃H₂₇N₃O₄S
Molecular Weight:441.551
Hs Code.:

Synonyms:N-{1-[4-(phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-acrylamide

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Chemical Property of N-{1-[4-(phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-acrylamide

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Technology Process of N-{1-[4-(phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-acrylamide

There total 6 articles about N-{1-[4-(phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1414968-26-5
{1-[4-(Phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

: 814-68-6,25189-84-8
acryloyl chloride

: 1414967-42-2
N-{1-[4-(phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-acrylamide

Guidance literature:: {1-[4-(Phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

acryloyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1414967-42-2
N-{1-[4-(phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 20 h / 60 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 4 h / 70 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.2: 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 66176-39-4
4-(bromomethyl)benzene-1-sulfonyl chloride

: 1414967-42-2
N-{1-[4-(phenylacetylamino-methyl)-benzenesulfonyl]-piperidin-4-yl}-acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 20 h / 60 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 4 h / 70 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

5.2: 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;