methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Base Information

Chemical Name:methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate
CAS No.:1373278-93-3
Molecular Formula:C₃₁H₂₇FN₄O₅
Molecular Weight:554.578
Hs Code.:

Synonyms:methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Property of methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Technology Process of methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

There total 9 articles about methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 61841-34-7
2-isopropenylbenzoxazole

: 1373278-67-1
methyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

: 1373278-93-3
methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: With sodium hypochlorite; In dichloromethane; at 20 ℃;

Reference yield:

: 1373278-04-6
4-bromo-2-(6-methoxy-6-oxohexanamido)benzoic acid

: 1373278-93-3
methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: acetic anhydride / 5 h / 150 °C

2: acetic acid / 1 h / 100 °C

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 70 °C

4: ozone / 0.67 h / -78 °C

5: hydroxylamine hydrochloride; pyridine / 2 h / 60 °C

6: sodium hypochlorite / dichloromethane / 20 °C

With pyridine; sodium hypochlorite; hydroxylamine hydrochloride; acetic anhydride; sodium carbonate; ozone; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1373278-06-8
methyl 5-(7-bromo-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

: 1373278-93-3
methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 70 °C

2: ozone / 0.67 h / -78 °C

3: hydroxylamine hydrochloride; pyridine / 2 h / 60 °C

4: sodium hypochlorite / dichloromethane / 20 °C

With pyridine; sodium hypochlorite; hydroxylamine hydrochloride; sodium carbonate; ozone; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; dichloromethane; water;