2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Base Information

• Chemical Name: 2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester
• CAS No.: 862080-81-7
• Molecular Formula: C₂₉H₄₈O₇SSi₂
• Molecular Weight: 596.933

Synonyms:2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Chemical Property of 2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

There total 3 articles about 2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester (862080-78-2) + 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → 2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-81-7)

Guidance literature:

2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester; With pyridine; silver nitrate; In tetrahydrofuran; at 20 ℃; for 1h;

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1021/jo0506985

Reference yield:

C11H18O3S (849112-79-4) → 2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-81-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 91 percent / aq. HCl / tetrahydrofuran / 8 h / 20 °C

2.1: DABCO; DMAP / CH₂Cl₂ / 9 h / 20 °C

3.1: AgNO₃; pyridine / tetrahydrofuran / 1 h / 20 °C

3.2: 97 percent / tetrahydrofuran / 6 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; dmap; silver nitrate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0506985

Reference yield:

(3R,4S,5R,6S)-1-thia-spiro[4,4]nonane-3,4,6-triol (862080-75-9) → 2,4-Dimethoxy-benzoic acid (1R,4R,5S,11S)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.01,5]tetradec-4-yl ester (862080-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: DABCO; DMAP / CH₂Cl₂ / 9 h / 20 °C

2.1: AgNO₃; pyridine / tetrahydrofuran / 1 h / 20 °C

2.2: 97 percent / tetrahydrofuran / 6 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; silver nitrate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0506985

upstream raw materials:

2,4-Dimethoxy-benzoic acid (3R,4S,5R,6S)-4,6-dihydroxy-1-thia-spiro[4.4]non-3-yl ester

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

C₁₁H₁₈O₃S

(3R,4S,5R,6S)-1-thia-spiro[4,4]nonane-3,4,6-triol

Downstream raw materials:

2,4-Dimethoxy-benzoic acid (1R,2R,4R,5S,11S)-7,7,9,9-tetraisopropyl-2-oxo-6,8,10-trioxa-2λ⁴-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-7,7,9,9-tetraisopropyl-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

2,4-Dimethoxy-benzoic acid (1R,3R,4R,5S,11S)-3-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-7,7,9,9-tetraisopropyl-6,8,10-trioxa-2-thia-7,9-disila-tricyclo[9.3.0.0^1,5]tetradec-4-yl ester

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