(5S)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one

Base Information

Chemical Name:(5S)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one
CAS No.:934196-34-6
Molecular Formula:C₁₇H₂₁NO₃
Molecular Weight:287.359
Hs Code.:

Synonyms:(5S)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one

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Chemical Property of (5S)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one

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Technology Process of (5S)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one

There total 2 articles about (5S)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 934196-27-7
4,5‐dimethyl‐3‐((S)‐1‐phenylethyl)oxazol‐2(3H)‐one

: 78-94-4,25038-87-3
methyl vinyl ketone

: 934196-34-6
(5S)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one

: (5R)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one

Guidance literature:: In 5,5-dimethyl-1,3-cyclohexadiene; at 100 ℃; for 72h; optical yield given as %de;
DOI:10.1016/j.tetlet.2010.05.034

Reference yield:

: 14649-03-7
(S)-phenylethyl isocyanate

: 934196-34-6
(5S)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one

: (5R)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 0.13 h / 140 °C / Sealed tube; Inert atmosphere; Microwave irradiation

2: 5,5-dimethyl-1,3-cyclohexadiene / 72 h / 100 °C / Sealed tube; Inert atmosphere

With triethylamine; In 5,5-dimethyl-1,3-cyclohexadiene; 2: |Michael Addition;
DOI:10.1002/chir.23109

Reference yield: 96.0%

: 934196-34-6
(5S)‐5‐methyl‐4‐methylene‐5‐(3‐oxobutyl)‐3‐((S)‐1‐phenylethyl)oxazolidin‐2‐one

: 1234623-26-7
C₁₆H₁₉NO₄

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 24h; chemoselective reaction;
DOI:10.1016/j.tetlet.2010.05.034