4-cyclopropyl-3-fluoro-5-(1H-tetrazol-1-yl)benzenamine

Base Information

Chemical Name:4-cyclopropyl-3-fluoro-5-(1H-tetrazol-1-yl)benzenamine
CAS No.:1356493-53-2
Molecular Formula:C₁₀H₁₀FN₅
Molecular Weight:219.221
Hs Code.:

Synonyms:4-cyclopropyl-3-fluoro-5-(1H-tetrazol-1-yl)benzenamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-cyclopropyl-3-fluoro-5-(1H-tetrazol-1-yl)benzenamine

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Technology Process of 4-cyclopropyl-3-fluoro-5-(1H-tetrazol-1-yl)benzenamine

There total 6 articles about 4-cyclopropyl-3-fluoro-5-(1H-tetrazol-1-yl)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1356493-52-1
1-(2-cyclopropyl-3-fluoro-5-nitrophenyl)-1H-tetrazole

: 1356493-53-2
4-cyclopropyl-3-fluoro-5-(1H-tetrazol-1-yl)benzenamine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; water; for 1h;

Reference yield:

: 367-12-4
2-fluorophenol

: 1356493-53-2
4-cyclopropyl-3-fluoro-5-(1H-tetrazol-1-yl)benzenamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid / dichloromethane / 0 - 20 °C

2.1: phosphorus tribromide / N,N-dimethyl-formamide; toluene / 1 h / 20 - 110 °C

3.1: acetic acid / iron / 1.5 h / 20 °C

4.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

5.1: trimethylsilylazide; acetic acid / 7 h / 70 °C

5.2: pH 12 - 14 / Cooling with ice

6.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h

With trimethylsilylazide; hydrogen; nitric acid; phosphorus tribromide; caesium carbonate; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; iron; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 2265-90-9
2-hydroxy-1,5-dinitro-3-fluorobenzene

: 1356493-53-2
4-cyclopropyl-3-fluoro-5-(1H-tetrazol-1-yl)benzenamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus tribromide / N,N-dimethyl-formamide; toluene / 1 h / 20 - 110 °C

2.1: acetic acid / iron / 1.5 h / 20 °C

3.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

4.1: trimethylsilylazide; acetic acid / 7 h / 70 °C

4.2: pH 12 - 14 / Cooling with ice

5.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h

With trimethylsilylazide; hydrogen; phosphorus tribromide; caesium carbonate; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; iron; In ethanol; water; N,N-dimethyl-formamide; toluene;