Technology Process of (S)-3-(Iodomethyl-dimethyl-silanyloxy)-2,2-dimethyl-cyclohexanone
There total 1 articles about (S)-3-(Iodomethyl-dimethyl-silanyloxy)-2,2-dimethyl-cyclohexanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / imidazole / CH2Cl2 / 1.5 h
2: 98 percent / NaI / acetone / 10 h / Heating
With
1H-imidazole; sodium iodide;
In
dichloromethane; acetone;
DOI:10.1016/j.tetlet.2004.09.143
- Guidance literature:
-
(S)-3-(Iodomethyl-dimethyl-silanyloxy)-2,2-dimethyl-cyclohexanone;
With
tert.-butyl lithium;
In
tetrahydrofuran;
at -78 ℃;
for 0.0833333h;
With
potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 10h;
Further stages.;
DOI:10.1016/j.tetlet.2007.07.179
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tBuLi / tetrahydrofuran / 0.08 h / -78 °C
1.2: H2O2; KHCO3; KF / tetrahydrofuran; methanol / 10 h / 20 °C
2.1: CSA / 1 h / 20 °C
2.2: Dess-Martin periodinane / CH2Cl2 / 2 h / 20 °C
3.1: TMSOTf; DIPEA / CH2Cl2 / 2 h / -20 °C
3.2: MeLi / tetrahydrofuran / 0.5 h / 20 °C
3.3: tetrahydrofuran / 9 h / 0 - 20 °C
4.1: H2NNH2; Et3N / ethanol / 120 h / Heating
4.2: I2; DBU / diethyl ether; benzene / 2 h / Heating
5.1: 94 percent / PTSA / methanol; H2O / 12 h / Heating
6.1: 100 percent / CSA / CH2Cl2 / 1 h / 20 °C
With
trimethylsilyl trifluoromethanesulfonate; camphor-10-sulfonic acid; tert.-butyl lithium; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
1.2: Tamao oxidation reaction / 2.2: Dess-Martin oxidation reaction;
DOI:10.1016/j.tetlet.2007.07.179
