2-hydroxy-17β-(S)-(hydroxyphenylmethyl)-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratrien-2-ol

Base Information

Chemical Name:2-hydroxy-17β-(S)-(hydroxyphenylmethyl)-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratrien-2-ol
CAS No.:791595-58-9
Molecular Formula:C₂₈H₃₆O₄
Molecular Weight:436.591
Hs Code.:

Synonyms:2-hydroxy-17β-(S)-(hydroxyphenylmethyl)-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratrien-2-ol

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Chemical Property of 2-hydroxy-17β-(S)-(hydroxyphenylmethyl)-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratrien-2-ol

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Technology Process of 2-hydroxy-17β-(S)-(hydroxyphenylmethyl)-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratrien-2-ol

There total 1 articles about 2-hydroxy-17β-(S)-(hydroxyphenylmethyl)-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratrien-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 791595-57-8
17β-O-benzyl-3-O-methoxymethyl-17α-methylestradiol

: 791595-58-9
2-hydroxy-17β-(S)-(hydroxyphenylmethyl)-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratrien-2-ol

Guidance literature:: 17β-O-benzyl-3-O-methoxymethyl-17α-methylestradiol; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -78 - -30 ℃; for 5h;

With Trimethyl borate; In tetrahydrofuran; cyclohexane; at -30 - 20 ℃; for 8h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; cyclohexane; at 0 - 20 ℃; for 8h;
DOI:10.1021/jm049647a

Reference yield: 87.0%

: 74-88-4
methyl iodide

: 791595-58-9
2-hydroxy-17β-(S)-(hydroxyphenylmethyl)-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratrien-2-ol

: 17β-(S)-(hydroxyphenylmethyl)-2-methoxy-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratriene

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 24h;
DOI:10.1021/jm049647a

Reference yield:

: 791595-58-9
2-hydroxy-17β-(S)-(hydroxyphenylmethyl)-3-O-methoxymethyl-17α-methyl-1,3,5(10)-estratrien-2-ol

: 17β-(S)-(hydroxyphenylmethyl)-2-methoxy-17α-methyl-1,3,5(10)-estratrien-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / K₂CO₃ / acetone / 24 h / 20 °C

2: 69 percent / aq. HCl / methanol; propan-2-ol / 6 h / 20 °C

With hydrogenchloride; potassium carbonate; In methanol; isopropyl alcohol; acetone;
DOI:10.1021/jm049647a