N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

Base Information

• Chemical Name: N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide
• CAS No.: 1070978-04-9
• Molecular Formula: C₂₈H₂₇N₅O₄
• Molecular Weight: 497.553
• Mol file: 1070978-04-9.mol

Synonyms:N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

Chemical Property of N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide

There total 11 articles about N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-(3-aminophenyl)-4-(pyrrolidin-1-yl)butanamide (851651-89-3) + N,N'-Di(2-carboxyphenyl)urea (4471-39-0) → N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide (1070978-04-9)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

Reference yield: 51.0%

N-(3-aminophenyl)-3-(pyrrolidin-1-yl)propanamide (851651-87-1) + N,N'-Di(2-carboxyphenyl)urea (4471-39-0) → N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide (1070978-04-9)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 22h;

Reference yield:

ortho-nitrobenzoic acid (552-16-9,104810-18-6) → N-(3-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide (1070978-04-9)

Guidance literature:

Multi-step reaction with 5 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 4 h / 0 - 20 °C

2: hydrogen / palladium on activated charcoal / methanol / 3.5 h

3: tetrahydrofuran / 48 h / Heating / reflux

4: trifluoroacetic acid / 1 h / 20 °C

5: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 22 h / 20 °C

With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

N-(3-aminophenyl)-3-(pyrrolidin-1-yl)propanamide

N,N'-Di(2-carboxyphenyl)urea

N-(3-aminophenyl)-4-(pyrrolidin-1-yl)butanamide

N-(3-nitrophenyl)-3-(pyrrolidin-1-yl)propanamide