(3R,4S)-tert-butyl 4-((S)-2-(benzyloxycarbonylamino)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoate

Base Information

Chemical Name:(3R,4S)-tert-butyl 4-((S)-2-(benzyloxycarbonylamino)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoate
CAS No.:149606-52-0
Molecular Formula:C₂₆H₄₂N₂O₆
Molecular Weight:478.629
Hs Code.:

Synonyms:(3R,4S)-tert-butyl 4-((S)-2-(benzyloxycarbonylamino)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoate

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Chemical Property of (3R,4S)-tert-butyl 4-((S)-2-(benzyloxycarbonylamino)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoate

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Technology Process of (3R,4S)-tert-butyl 4-((S)-2-(benzyloxycarbonylamino)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoate

There total 4 articles about (3R,4S)-tert-butyl 4-((S)-2-(benzyloxycarbonylamino)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 161712-03-4
t-butyl-(3R,4S)-4-(N-methylamino)-3-methoxy-5-methyl-hexanoate

: 149606-52-0
(3R,4S)-tert-butyl 4-((S)-2-(benzyloxycarbonylamino)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoate

Guidance literature:: With dicyclohexyl-carbodiimide; In acetonitrile; Yield given; a) 0 deg C, 3 h, b) RT, 16 h;
DOI:10.1248/cpb.43.1706

Reference yield:

: 149606-47-3
(3R,4S)-tert-butyl 4-((benzyloxycarbonyl)(methyl)amino)-3-methoxy-5-methylhexanoate

: 149606-52-0
(3R,4S)-tert-butyl 4-((S)-2-(benzyloxycarbonylamino)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / 2-methyl-propan-2-ol; H₂O / 2 h

2: 1,3-dicyclohexylcarbodiimide / acetonitrile / a) 0 deg C, 3 h, b) RT, 16 h

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; acetonitrile; tert-butyl alcohol;
DOI:10.1248/cpb.43.1706

Reference yield:

: 1053701-87-3
(3R,4S)-4-(Benzyloxycarbonyl-methyl-amino)-3-methoxy-5-methyl-hexanoic acid

: 149606-52-0
(3R,4S)-tert-butyl 4-((S)-2-(benzyloxycarbonylamino)-N,3-dimethylbutanamido)-3-methoxy-5-methylhexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂SO₄ / CH₂Cl₂

2: H₂ / 5percent Pd/C / 2-methyl-propan-2-ol; H₂O / 2 h

3: 1,3-dicyclohexylcarbodiimide / acetonitrile / a) 0 deg C, 3 h, b) RT, 16 h

With sulfuric acid; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1248/cpb.43.1706