Technology Process of ethyl (2S,3R)-3-bromo-2-hydroxy-3-phenylpropionate
There total 4 articles about ethyl (2S,3R)-3-bromo-2-hydroxy-3-phenylpropionate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
magnesium bromide;
In
diethyl ether;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / K3FeCN6; K2CO3; (DHQ)2PHAL / OsO4 / 2-methyl-propan-2-ol; H2O; toluene / 48 h / 20 °C
2: 96 percent / SOCl2 / pyridine / 5 h / 0 °C
3: 92 percent / NaIO4; RuCl3 / CCl4; acetonitrile; H2O / 0.5 h / 0 °C
4: 70 percent / MgBr2 / diethyl ether / 12 h / 20 °C
With
ruthenium trichloride; sodium periodate; thionyl chloride; Hydroquinone 1,4-phthalazinediyl diether; potassium carbonate; magnesium bromide; potassium hexacyanoferrate(III);
osmium(VIII) oxide;
In
pyridine; tetrachloromethane; diethyl ether; water; toluene; acetonitrile; tert-butyl alcohol;
1: hydroxylation / 2: Cyclization / 3: Oxidation / 4: Ring cleavage;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 96 percent / SOCl2 / pyridine / 5 h / 0 °C
2: 92 percent / NaIO4; RuCl3 / CCl4; acetonitrile; H2O / 0.5 h / 0 °C
3: 70 percent / MgBr2 / diethyl ether / 12 h / 20 °C
With
ruthenium trichloride; sodium periodate; thionyl chloride; magnesium bromide;
In
pyridine; tetrachloromethane; diethyl ether; water; acetonitrile;
1: Cyclization / 2: Oxidation / 3: Ring cleavage;
