108741-14-6Relevant academic research and scientific papers
Catalysts/cosolvents and general acid catalysts for acceleration of the hydrolysis of osmate(VI) esters
Junttila, Mikko H.,Hormi, Osmo E.O.
, p. 3430 - 3432 (2010)
New catalysts/cosolvents as hydrolysis aids and the properties of the catalyst/cosolvent that effect the efficiency of the hydrolysis aid for the hydrolysis of osmate(VI) esters of aliphatic olefins are presented. Also, the effect of pH of the reaction media on the specific and general acid-catalysed hydrolysis of osmate(VI) esters of conjugated aromatic olefins is presented.
Catalytic asymmetric dihydroxylation using phenoxyethoxymethyl-polystyrene (PEM)-based novel microencapsulated osmium tetroxide (PEM-MC OsO4)
Kobayashi, Shu,Ishida, Tasuku,Akiyama, Ryo
, p. 2649 - 2651 (2001)
(Equation presented) A phenoxyethoxymethyl-polystyrene (PEM)-based novel polymer-supported osmium catalyst has been developed. The catalyst was readily prepared from PEM polymer based on a microencapsulation technique, and asymmetric dihydroxylation of olefins has been successfully performed using (DHQD)2PHAL as a chiral ligand and K3Fe(CN)6 as a cooxidant in H20/acetone. The catalyst was recovered quantitativery by simple filtration and reused without loss of activity several times.
COVALENT RAS INHIBITORS AND USES THEREOF
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Page/Page column 152, (2021/06/04)
The disclosure features compounds, or pharmaceutically acceptable salts thereof, alone and in combination with other therapeutic agents, pharmaceutical compositions, and protein conjugates thereof, capable of modulating biological processes including Ras, and their uses in the treatment of cancers.
RAS INHIBITORS
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Paragraph 1294-1295, (2021/05/07)
The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
Investigation for the cyclization efficiency of linear tetrapeptides: Synthesis of tentoxin B and dihydrotentoxin
Sato, Ryota,Oyama, Kie,Konno, Hiroyuki
supporting information, p. 6173 - 6181 (2018/09/17)
Investigation of the cyclization efficiency of N-methyl linear tetrapeptides using a molecular modeling study and chemical synthesis is described. The linear peptide with two N-methyl groups, MeAla-Leu-MePhe-Gly, forms γ-turn like conformation with the am
Osmium on chelate resin: Nonvolatile catalyst for the synthesis of DIOLS from alkenes
Monguchi, Yasunari,Wakayama, Fumika,Takada, Hitoshi,Sawama, Yoshinari,Sajiki, Hironao
supporting information, p. 700 - 704 (2015/03/14)
Osmium tetraoxide (OsO4) was immobilized on a commercially available chelate resin DIAION CR11 (CR11) just by simply immersing it in a methanol solution of OsO4 at room temperature. The resulting purple solid, 5% Os/CR11, indicated no volatility, and effectively catalyzed the oxidation of various alkenes to the corresponding diols.
Synthesis of amino thiols and isocysteines via regioselective ring opening of sulfamidates with tetrathiomolybdate
Nasir Baig,Phani Kumar,Mannuthodikayil, Jamsad,Chandrasekaran, Srinivasan
scheme or table, p. 3111 - 3118 (2011/05/17)
Herein we present a simple and highly efficient method for the synthesis of β and γ-amino thiols via regioselective ring opening of sulfamidates with tetrathiomolybdate 1. The generality of this methodology has been shown by synthesizing carbohydrate deri
Highly enantioselective synthesis of anti aryl β-hydroxy α-amino esters via DKR transfer hydrogenation
Liu, Zhuqing,Shultz, C.Scott,Sherwood, Candice A.,Krska, Shane,Dormer, Peter G.,Desmond, Richard,Lee, Claire,Sherer, Edward C.,Shpungin, Joseph,Cuff, James,Xu, Feng
scheme or table, p. 1685 - 1688 (2011/05/05)
An efficient preparation of highly enantiomerically enriched aryl β-hydroxy α-amino esters via dynamic kinetic resolution (DKR), asymmetric transfer hydrogenation of α-amino β-keto esters is described. The anti β-hydroxyl α-amino esters were obtained both in high yields and high diasteroselectivity. The observed high anti selectivity is inconsistent with the previous results in literature. The absolute stereochemistry of the aryl β-hydroxy α-amino esters was unambiguously confirmed via chemical derivatization as well as Vibrational Circular Dichroism (VCD) techniques.
Synthesis of unnatural selenocystines and β-aminodiselenides via regioselective ring-opening of sulfamidates using a sequential, one-pot, multistep strategy
Rashid Baig, Nasir Baig,Chandrakala,Sudhir, V. Sai,Chandrasekaran, Srinivasan
scheme or table, p. 2910 - 2921 (2010/07/15)
A variety of N-alkyl-β-aminodiselenides have been synthesized in high yield from sulfamidates under mild reaction conditions using potassium selenocyanate and benzyltriethylammonium tetrathiomolybdate ([BnNEt 3]2MoS4) in a sequential, one-pot, multistep reaction. The tolerance of multifarious protecting groups under the reaction conditions is discussed. The methodology was successfully extended to the synthesis of selenocystine, 3,3′-dialkylselenocystine, and 3,3′-diphenylisoselenocystine and their direct incorporation into peptides.
Structure-activity relationship (SAR) studies of 3-(2-amino-ethyl)-5-(4-ethoxy-benzylidene)-thiazolidine-2,4-dione: Development of potential substrate-specific ERK1/2 inhibitors
Li, Qianbin,Al-Ayoubi, Adnan,Guo, Tailiang,Zheng, Hui,Sarkar, Aurijit,Nguyen, Tri,Eblen, Scott T.,Grant, Steven,Kellogg, Glen E.,Zhang, Shijun
scheme or table, p. 6042 - 6046 (2010/05/18)
A series of analogs of 3-(2-amino-ethyl)-5-(4-ethoxy-benzylidene)-thiazolidine-2,4-dione, a putative substrate-specific ERK1/2 inhibitor, were synthesized and biologically characterized in human leukemia U937 cells to define its pharmacophore. It was disc
